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    Ctr1C Copper transporter 1C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctr1Cprovided by FlyBase
    Official Full Name
    Copper transporter 1Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0062411
    Locus tag
    Dmel_CG15551
    See related
    AllianceGenome:FB:FBgn0062411
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT31946; CG15551; Dmel\CG15551; FBgn0039813
    Summary
    Enables copper ion transmembrane transporter activity. Involved in copper ion import and spermatogenesis. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ctr1C in Genome Data Viewer
    Location:
    100B1-100B1; 3-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30963290..30964320, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26789012..26790042, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene 5-hydroxytryptamine (serotonin) receptor 7 Neighboring gene long non-coding RNA:CR46116 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila copper transporter Ctr1C functions in male fertility. Steiger D, et al. J Biol Chem, 2010 May 28. PMID 20351114, Free PMC Article
    2. Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects. Hua H, et al. J Biol Inorg Chem, 2010 Jan. PMID 19856191
    3. Mechanism of silver nanoparticles action on insect pigmentation reveals intervention of copper homeostasis. Armstrong N, et al. PLoS One, 2013. PMID 23308159, Free PMC Article
    4. A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. Zhou H, et al. J Biol Chem, 2003 Nov 28. PMID 12966081
    5. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. Lang M, et al. Neurobiol Aging, 2013 Nov. PMID 23827522, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in copper ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper transporter 1C
    Names
    CG15551-PA
    Ctr1C-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30963290..30964320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143580.3 → NP_651837.1  copper transporter 1C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8R3, Q9VA22
      Related
      FBpp0085111
      Conserved Domains (2) summary
      pfam04145
      Location:63 → 258
      Ctr; Ctr copper transporter family
      pfam04592
      Location:23 → 56
      SelP_N; Selenoprotein P, N terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8R3 Q8T8R3
    Q9VA22 Q9VA22

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