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    ltl larval translucida [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ltlprovided by FlyBase
    Official Full Name
    larval translucidaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0268063
    Locus tag
    Dmel_CG32372
    See related
    AllianceGenome:FB:FBgn0268063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:CL1a11; CG14836; CG32372; CG7545; CT15760; Dmel\CG32372; F; l(3)tr; lincRNA.S4366; Ltl
    Summary
    Involved in imaginal disc-derived wing vein specification and negative regulation of BMP signaling pathway. Located in extracellular space. Is expressed in several structures, including anterior endoderm anlage; anterior-posterior compartment boundary of the wing blade; dorsal pharyngeal muscle cell; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to several human genes including CD180 (CD180 molecule); IGFALS (insulin like growth factor binding protein acid labile subunit); and LRRC17 (leucine rich repeat containing 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ltl in Genome Data Viewer
    Location:
    66A3-66A4; 3-21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7518997..7528013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7512097..7521113)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45896 Neighboring gene uncharacterized protein Neighboring gene liquid facets Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An investigation into the metamorphosis of the mutant lethal-translucida of Drosophila melanogaster. SOBELS FH, et al. Z Indukt Abstamm Vererbungsl, 1953. PMID 13170360
    2. Patterns of biochemical and developmental pleiotropy. HADORN E. Cold Spring Harb Symp Quant Biol, 1956. PMID 13433605
    3. [Experimental breeding of offsprings of lethal ovaries of a mutant letal-translucida from Drosophila melanogaster]. SOBELS FH. Experientia, 1950 Apr 15. PMID 15421309
    4. Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia. Hodgson JA, et al. Int J Mol Sci, 2021 Aug 2. PMID 34361081, Free PMC Article
    5. Combined modelling of mRNA decay dynamics and single-molecule imaging in the Drosophila embryo uncovers a role for P-bodies in 5' to 3' degradation. Forbes Beadle L, et al. PLoS Biol, 2023 Jan. PMID 36649329, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. larval translucida acts in the extracellular space where it completes a novel auto-regulatory loop that modulates BMP activity[larval translucida]
      Title: Feedback regulation of Drosophila BMP signaling by the novel extracellular protein larval translucida.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    larval translucida
    Names
    CG32372-PA
    CG32372-PB
    lethal (3) translucida
    lethal translucida
    ltl-PA
    ltl-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7518997..7528013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274595.1 → NP_001261524.1  larval translucida, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261524.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P15, Q9VS84
      Conserved Domains (4) summary
      cd00116
      Location:226 → 451
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:320 → 335
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:87 → 110
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:369 → 426
      LRR_8; Leucine rich repeat

    2. NM_168218.2 → NP_729265.1  larval translucida, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P15, Q9VS84
      Related
      FBpp0076507
      Conserved Domains (4) summary
      cd00116
      Location:226 → 451
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:320 → 335
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:87 → 110
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:369 → 426
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P15 Q86P15
    Q9VS84 Q9VS84

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