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    lqfR liquid facets-Related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lqfRprovided by FlyBase
    Official Full Name
    liquid facets-Relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261279
    Locus tag
    Dmel_CG42250
    See related
    AllianceGenome:FB:FBgn0261279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13853; CG13854; CG31170; CG31285; CG42250; Dmel\CG42250; dTel2; epsin; Epsin; epsin-like; epsin02; epsinR; l(3)03685; l(3)A9; l(3)dsl-9; l(3)dsl9; l(3)SG62; l(3)XII-10; Lqfr; LqfR; Tel2; XII-10
    Old locus tag
    Dmel_CG31170; Dmel_CG31285
    Summary
    Predicted to enable clathrin binding activity and phospholipid binding activity. Involved in oogenesis. Located in early endosome; nucleus; and trans-Golgi network. Is expressed in several structures, including embryonic/larval midgut primordium; germline cell; gland; gut section; and imaginal disc. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lqfR in Genome Data Viewer
    Location:
    94A12-94A12; 3-74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22411301..22419051)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18237023..18244773)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nop56 Neighboring gene mob as tumor suppressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination. Oldham CE, et al. Curr Biol, 2002 Jul 9. PMID 12121618
    2. Liquid facets-related (lqfR) is required for egg chamber morphogenesis during Drosophila oogenesis. Leventis PA, et al. PLoS One, 2011. PMID 22043285, Free PMC Article
    3. Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling. Lee JH, et al. PLoS One, 2012. PMID 23029494, Free PMC Article
    4. Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. Lee JH, et al. Dev Biol, 2009 Jul 1. PMID 19376106, Free PMC Article
    5. Numb: "Adapting" notch for endocytosis. Jafar-Nejad H, et al. Dev Cell, 2002 Aug. PMID 12194846

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At least one of the functions of Drosophila Tel2/EpsinR is regulation of Wingless signaling.
      Title: Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    liquid facets-Related
    Names
    CG42250-PC
    CG42250-PD
    EpsinR
    epsin-2
    epsin-like
    lethal (3) SG62
    liquid facet related
    liquid facets related
    liquid-facets related
    lqfR-PC
    lqfR-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22411301..22419051
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170009.4 → NP_732734.3  liquid facets-Related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732734.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SS7, Q9NH51, Q9VD13
      Conserved Domains (2) summary
      cd03571
      Location:27 → 150
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam15050
      Location:204 → 283
      SCIMP; SCIMP protein

    2. NM_170011.3 → NP_732736.2  liquid facets-Related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732736.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN05
      Conserved Domains (3) summary
      cd03571
      Location:27 → 150
      ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
      pfam10193
      Location:1072 → 1184
      Telomere_reg-2; Telomere length regulation protein
      pfam13254
      Location:226 → 459
      DUF4045; Domain of unknown function (DUF4045)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IN05 Q8IN05
    Q9NH51 Q9NH51
    Q9VD13 Q9VD13

    Gene LinkOut

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