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    CG6287 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6287provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032350
    Locus tag
    Dmel_CG6287
    See related
    AllianceGenome:FB:FBgn0032350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6287; GH26
    Summary
    Predicted to enable phosphoglycerate dehydrogenase activity. Predicted to be involved in serine family amino acid biosynthetic process. Is expressed in adult head; adult heart; and organism. Used to study PHGDH deficiency. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6287 in Genome Data Viewer
    Location:
    32D5-32D5; 2-44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11151506..11155721, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11151506..11155721, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase at 32E Neighboring gene homogentisate 1,2-dioxygenase Neighboring gene uncharacterized protein Neighboring gene Ca2+-channel-protein-beta-subunit Neighboring gene Vitelline membrane 32E Neighboring gene Buddy of Hmr 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutritional geometry framework of sleep. Lai ML, et al. Life Sci, 2023 Mar 1. PMID 36640899
    2. Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila. Wang R, et al. Nat Commun, 2022 Jun 20. PMID 35725845, Free PMC Article
    3. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article
    4. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Mattila J, et al. Cell Rep, 2015 Oct 13. PMID 26440885
    5. A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies. Laslo M, et al. Age (Dordr), 2013 Aug. PMID 22639178, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c11154293-11154012 mobile_element_type = transposon:INE-1{}6252

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycerate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglycerate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in serine family amino acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6287-PA
    NP_609496.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11151506..11155721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135652.3 → NP_609496.1  uncharacterized protein Dmel_CG6287 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKI8
      Related
      FBpp0079809
      Conserved Domains (2) summary
      COG0111
      Location:5 → 315
      SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
      cd12173
      Location:7 → 311
      PGDH_4; Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKI8 Q9VKI8

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