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    CG6230 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6230provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027582
    Locus tag
    Dmel_CG6230
    See related
    AllianceGenome:FB:FBgn0027582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH06032; dCOD1; Dmel\CG6230
    Summary
    Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type ion transporter activity; and membrane protein dislocase activity. Predicted to be involved in extraction of mislocalized protein from ER membrane; intracellular calcium ion homeostasis; and transmembrane transport. Located in endomembrane system. Is expressed in adult head and spermatozoon. Orthologous to human ATP13A1 (ATPase 13A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6230 in Genome Data Viewer
    Location:
    32D4-32D4; 2-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11115635..11120319, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11115635..11120319, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RALBP1 associated Eps domain containing Neighboring gene lethal (2) giant discs 1 Neighboring gene alpha-L-iduronidase Neighboring gene Gustatory receptor 32a Neighboring gene Dynein axonemal assembly factor 4 Neighboring gene Csl4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. Cronin SR, et al. J Cell Biol, 2002 Jun 10. PMID 12058017, Free PMC Article
    2. Genetic dissection of Nucleoporin 160 (Nup160), a gene involved in multiple phenotypes of reproductive isolation in Drosophila. Maehara K, et al. Genes Genet Syst, 2012. PMID 22820383
    3. Drosophila oocyte proteome composition covaries with female mating status. McDonough-Goldstein CE, et al. Sci Rep, 2021 Feb 4. PMID 33542461, Free PMC Article
    4. Introgression of Drosophila simulans nuclear pore protein 160 in Drosophila melanogaster alone does not cause inviability but does cause female sterility. Sawamura K, et al. Genetics, 2010 Oct. PMID 20647504, Free PMC Article
    5. P-type ATPases in Caenorhabditis and Drosophila: implications for evolution of the P-type ATPase subunit families with special reference to the Na,K-ATPase and H,K-ATPase subgroup. Okamura H, et al. J Membr Biol, 2003 Jan 1. PMID 12532273

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type ion transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane protein dislocase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in extraction of mislocalized protein from ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6230-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11115635..11120319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135646.3 → NP_609490.1  uncharacterized protein Dmel_CG6230 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VKJ6, Q9Y139
      Related
      FBpp0079815
      Conserved Domains (4) summary
      COG4087
      Location:850 → 901
      COG4087; Soluble P-type ATPase [General function prediction only]
      TIGR01657
      Location:109 → 1193
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:310 → 515
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:590 → 664
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSI5 Q8MSI5
    Q9VKJ6 Q9VKJ6
    Q9Y139 Q9Y139

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