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    CG5555 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5555provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038686
    Locus tag
    Dmel_CG5555
    See related
    AllianceGenome:FB:FBgn0038686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5555
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in Ras protein signal transduction and protein ubiquitination. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to human BRAP (BRCA1 associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5555 in Genome Data Viewer
    Location:
    91F10-91F11; 3-66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19178085..19180538, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15003807..15006260, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene squeeze Neighboring gene uncharacterized protein Neighboring gene mayday Neighboring gene long non-coding RNA:CR46039 Neighboring gene long non-coding RNA:CR46393 Neighboring gene cryptochrome

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modifiers of muscle and heart cell fate specification identified by gain-of-function screen in Drosophila. Bidet Y, et al. Mech Dev, 2003 Sep. PMID 14550529
    2. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
    3. Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. Hoopfer ED, et al. J Neurosci, 2008 Jun 11. PMID 18550751, Free PMC Article
    4. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407
    5. A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. Port F, et al. Elife, 2020 Feb 13. PMID 32053108, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5555-PA
    CG5555-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19178085..19180538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275795.1 → NP_001262724.1  uncharacterized protein Dmel_CG5555, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHR2
      Conserved Domains (5) summary
      cd12718
      Location:150 → 234
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam02148
      Location:304 → 363
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      pfam10473
      Location:366 → 517
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam13639
      Location:249 → 291
      zf-RING_2; Ring finger domain
      pfam13863
      Location:396 → 517
      DUF4200; Domain of unknown function (DUF4200)

    2. NM_142532.3 → NP_650789.1  uncharacterized protein Dmel_CG5555, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961U3, Q9VDZ1
      Related
      FBpp0083160
      Conserved Domains (5) summary
      cd12718
      Location:147 → 231
      RRM_BRAP2; RNA recognition motif in BRCA1-associated protein (BRAP2)
      pfam02148
      Location:301 → 360
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
      pfam10473
      Location:363 → 514
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam13639
      Location:246 → 288
      zf-RING_2; Ring finger domain
      pfam13863
      Location:393 → 514
      DUF4200; Domain of unknown function (DUF4200)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHR2 A0A0B4KHR2
    Q9VDZ1 Q9VDZ1

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