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    hob hobbit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hobprovided by FlyBase
    Official Full Name
    hobbitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035420
    Locus tag
    Dmel_CG14967
    See related
    AllianceGenome:FB:FBgn0035420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14967; Dmel\CG14967; sP2
    Summary
    Enables phosphatidylinositol binding activity. Located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Is expressed in adult head; organism; and spermatozoon. Orthologous to human BLTP2 (bridge-like lipid transfer protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hob in Genome Data Viewer
    Location:
    63B13-63B14; 3-6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3210992..3218920, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3210992..3218920, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene gryzun Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene neutral sphingomyelinase Neighboring gene Ribosomal protein L28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Hob proteins: Putative, novel lipid transfer proteins at ER-PM contact sites. Neuman SD, et al. Contact (Thousand Oaks), 2021 Jan-Dec. PMID 36589899, Free PMC Article
    2. Hobbit regulates intracellular trafficking to drive insulin-dependent growth during Drosophila development. Neuman SD, et al. Development, 2018 Jun 11. PMID 29891564, Free PMC Article
    3. The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites. Neuman SD, et al. J Cell Sci, 2022 Mar 1. PMID 34415038, Free PMC Article
    4. Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance. Takechi H, et al. Elife, 2021 Mar 5. PMID 33666170, Free PMC Article
    5. Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA. Vilmos P, et al. Genetics, 2013 Oct. PMID 23852386, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites.
      Title: The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of positive regulation of regulated secretory pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-plasma membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hobbit
    Names
    CG14967-PB
    CG14967-PC
    hob-PB
    hob-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3210992..3218920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139532.2 → NP_647789.2  hobbit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647789.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZS7
      Conserved Domains (4) summary
      pfam10293
      Location:887 → 959
      DUF2405; Domain of unknown function (DUF2405)
      pfam10344
      Location:26 → 666
      Fmp27; Mitochondrial protein from FMP27
      pfam10347
      Location:1071 → 1203
      Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
      pfam10351
      Location:1774 → 2239
      Apt1; Golgi-body localization protein domain

    2. NM_001316473.1 → NP_001303402.1  hobbit, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VZS7
      Conserved Domains (4) summary
      pfam10293
      Location:887 → 959
      DUF2405; Domain of unknown function (DUF2405)
      pfam10344
      Location:26 → 666
      Fmp27; Mitochondrial protein from FMP27
      pfam10347
      Location:1071 → 1203
      Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
      pfam10351
      Location:1774 → 2239
      Apt1; Golgi-body localization protein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLX1 Q8MLX1
    Q9VZS7.2 Q9VZS7

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