Mtpbeta Mitochondrial trifunctional protein beta subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mtpbetaprovided by FlyBase
Official Full Name: Mitochondrial trifunctional protein beta subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0025352
Locus tag: Dmel_CG4581
See related: AllianceGenome:FB:FBgn0025352
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ACoT; CG4581; dHADHB; Dmel\CG4581; l(2)k09828; MTP; thiolase; Thiolase
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity. Involved in determination of adult lifespan and fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; germline cell; gut section; and visceral mesoderm derivative. Used to study lipid metabolism disorder; mitochondrial trifunctional protein deficiency; and steatotic liver disease. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60A5-60A5; 2-105 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23866648..23868603, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19754171..19756126, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both Mtpalpha(KO) and Mtpbeta(KO) flies were impaired in long-chain fatty acid beta-oxidation; results strongly suggest that the functions of MTP are essentially conserved between mammals and Drosophila [Mtpalpha][Mtpbeta]
Title: Impaired fatty acid oxidation in a Drosophila model of mitochondrial trifunctional protein (MTP) deficiency.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial fatty acid beta-oxidation multienzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: mitochondrial trifunctional protein beta subunit

Names: CG4581-PA; Mtpbeta-PA; thiolase

NP_477378.1

EC 2.3.-.-

EC 2.3.1.-

EC 2.3.1.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23866648..23868603 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058030.4 → NP_477378.1 mitochondrial trifunctional protein beta subunit [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477378.1

Status: REVIEWED

UniProtKB/TrEMBL

O77466, Q9W1H8

Related

FBpp0072135

Conserved Domains (2) summary

PRK08963
Location:44 → 462

fadI; 3-ketoacyl-CoA thiolase; Reviewed

cd00751
Location:45 → 462

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...