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    Pglym78 Phosphoglyceromutase 78 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pglym78provided by FlyBase
    Official Full Name
    Phosphoglyceromutase 78provided by FlyBase
    Primary source
    FLYBASE:FBgn0014869
    Locus tag
    Dmel_CG1721
    See related
    AllianceGenome:FB:FBgn0014869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1721; Dmel\CG1721; PGAM; Pglym; PGLYM; pglym78
    Summary
    Predicted to enable 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity and bisphosphoglycerate mutase activity. Involved in canonical glycolysis. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; germline cell; larval muscle system; and muscle cell. Human ortholog(s) of this gene implicated in myoglobinuria. Orthologous to human PGAM1 (phosphoglycerate mutase 1); PGAM2 (phosphoglycerate mutase 2); and PGAM4 (phosphoglycerate mutase family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pglym78 in Genome Data Viewer
    Location:
    98F12-98F13; 3-97 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29148248..29149901)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24973970..24975623)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Suppressor of ER stress-induced death Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2D Neighboring gene Stem-loop binding protein Neighboring gene Regulatory particle non-ATPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure, expression and duplication of genes which encode phosphoglyceromutase of Drosophila melanogaster. Currie PD, et al. Genetics, 1994 Oct. PMID 7828819, Free PMC Article
    2. Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression. Sullivan E, et al. Genes Dev, 2001 Jan 15. PMID 11157774, Free PMC Article
    3. Analysis of glycolytic enzyme co-localization in Drosophila flight muscle. Sullivan DT, et al. J Exp Biol, 2003 Jun. PMID 12756285
    4. Ecdysone and 20-hydroxyecdysone are not required to activate glycolytic gene expression in Drosophila melanogaster embryos. Tennessen JM. MicroPubl Biol, 2021. PMID 34870111, Free PMC Article
    5. The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth. Tennessen JM, et al. Cell Metab, 2011 Feb 2. PMID 21284981, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables bisphosphoglycerate mutase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    phosphoglyceromutase 78
    Names
    CG1721-PA
    CG1721-PB
    CG1721-PC
    Pglym78-PA
    Pglym78-PB
    Pglym78-PC
    phosphoglycerate mutase
    phosphoglycerol mutase
    phosphoglyceromutase
    phosphogylcerate mutase 78
    NP_001034075.1
    NP_001034076.1
    NP_524546.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29148248..29149901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079822.3 → NP_524546.2  phosphoglyceromutase 78, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524546.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5XD87, A5XD88, Q961P1, Q9VAN7
      Related
      FBpp0084753
      Conserved Domains (1) summary
      cl11399
      Location:5 → 255
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    2. NM_001038986.3 → NP_001034075.1  phosphoglyceromutase 78, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5XD87, A5XD88, Q961P1, Q9VAN7
      Conserved Domains (1) summary
      cl11399
      Location:5 → 255
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

    3. NM_001038987.2 → NP_001034076.1  phosphoglyceromutase 78, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5XD87, A5XD88, Q961P1, Q9VAN7
      Conserved Domains (1) summary
      cl11399
      Location:5 → 255
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24450 Q24450
    Q9GU73 Q9GU73
    Q9VAN7 Q9VAN7

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