DopEcR Dopamine/Ecdysteroid receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: DopEcRprovided by FlyBase
Official Full Name: Dopamine/Ecdysteroid receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0035538
Locus tag: Dmel_CG18314
See related: AllianceGenome:FB:FBgn0035538
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.139; anon-WO0170980.140; CG18314; DmDopEcR; Dmel\CG18314; dop; DopECR
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gs and ecdysone binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to sucrose stimulus; and learning. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe; adult brain; adult head; adult mushroom body; and ganglia. Used to study alcohol use disorder and renal fibrosis. Orthologous to human GPR21 (G protein-coupled receptor 21) and GPR52 (G protein-coupled receptor 52). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4367649..4380387, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4367649..4380387, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables dopamine neurotransmitter receptor activity, coupled via Gs	IDA Inferred from Direct Assay more info	PubMed
enables ecdysone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to sucrose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in habituation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ecdysone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG18314-PA; CG18314-PB; CG18314-PC; DopEcR-PA; DopEcR-PB; DopEcR-PC; dopamine/ecdysteroid receptor

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