GlcAT-S Glucuronyltransferase S [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GlcAT-Sprovided by FlyBase
Official Full Name: Glucuronyltransferase Sprovided by FlyBase
Primary source: FLYBASE:FBgn0032135
Locus tag: Dmel_CG3881
See related: AllianceGenome:FB:FBgn0032135
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3881; dGlcAT-BSI; dGlcAT-S; DGlcAT-S; Dmel\CG3881; DmGlcAT-BSI
Summary: Enables glucuronosyltransferase activity. Predicted to be involved in carbohydrate metabolic process and chondroitin sulfate proteoglycan biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi membrane. Is expressed in adult head; germarium; hub cell; organism; and testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9616469..9623109)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9616469..9623109)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Study confirms results showing that GlcAT-S and GlcAT-P can transfer GlcA to the O-linked T-antigen as well as to N-linked LacNAc-chains in vitro.
Title: Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen.
novel glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans
Title: Identification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity toward oligosaccharides from proteoglycans, glycoproteins, and glycosphingolipids.

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Function	Evidence Code	Pubs
enables N-acetyllactosamine beta-1,3-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables asioloorosomucoid beta-1,3-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoprotein biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in glycosphingolipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in protein N-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in proteoglycan biosynthetic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_001162922.1

NP_609303.1

NP_723476.1

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The following sections contain reference sequences that belong to a specific genome build. Explain