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    CngB Cyclic nucleotide-gated ion channel subunit B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CngBprovided by FlyBase
    Official Full Name
    Cyclic nucleotide-gated ion channel subunit Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266346
    Locus tag
    Dmel_CG17922
    See related
    AllianceGenome:FB:FBgn0266346
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17922; Cncbeta; dCNCbeta; dmCNGB; Dmel\CG17922
    Summary
    Contributes to intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Involved in monoatomic cation transmembrane transport. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in achromatopsia 3; color blindness; retinitis pigmentosa; and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1) and CNGB3 (cyclic nucleotide gated channel subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CngB in Genome Data Viewer
    Location:
    57F9-57F9; 2-96 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21692691..21697152, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17580196..17584657, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Baramicin C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Translocase of inner membrane 10 Neighboring gene uncharacterized protein Neighboring gene Phosphopantothenoylcysteine decarboxylase Neighboring gene HMG protein Z Neighboring gene High mobility group protein D Neighboring gene long non-coding RNA:CR44749

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human. Finn JT, et al. Biophys J, 1998 Mar. PMID 9512030, Free PMC Article
    2. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. McCarroll SA, et al. Nat Genet, 2004 Feb. PMID 14730301
    3. Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Vermehren-Schmaedick A, et al. Genetics, 2010 Sep. PMID 20592263, Free PMC Article
    4. Dissection of a hypoxia-induced, nitric oxide-mediated signaling cascade. Dijkers PF, et al. Mol Biol Cell, 2009 Sep. PMID 19625446, Free PMC Article
    5. Cyclic nucleotide-gated ion channels. Kaupp UB, et al. Physiol Rev, 2002 Jul. PMID 12087135

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to intracellularly cyclic nucleotide-activated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intracellular cyclic nucleotide activated cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intracellular cyclic nucleotide activated cation channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclic nucleotide-gated ion channel subunit B
    Names
    CG17922-PA
    CG17922-PB
    CngB-PA
    CngB-PB
    Cyclic-nucleotide-gated ion channel protein beta-subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21692691..21697152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137763.4 → NP_611607.2  cyclic nucleotide-gated ion channel subunit B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611607.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH43, Q9W2D5
      Related
      FBpp0071592
      Conserved Domains (4) summary
      COG0664
      Location:769 → 898
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:775 → 889
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:488 → 704
      Ion_trans; Ion transport protein
      pfam13387
      Location:672 → 755
      DUF4105; Domain of unknown function (DUF4105)

    2. NM_001299764.1 → NP_001286693.1  cyclic nucleotide-gated ion channel subunit B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG93
      Conserved Domains (4) summary
      COG0664
      Location:716 → 845
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:722 → 836
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:435 → 651
      Ion_trans; Ion transport protein
      pfam13387
      Location:619 → 702
      DUF4105; Domain of unknown function (DUF4105)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG93 A0A0B4LG93
    Q95SL0 Q95SL0
    Q9W2D5 Q9W2D5

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