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    Sardh Sarcosine dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sardhprovided by FlyBase
    Official Full Name
    Sarcosine dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034276
    Locus tag
    Dmel_CG6385
    See related
    AllianceGenome:FB:FBgn0034276
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6385; Dmel\CG6385; sardh
    Summary
    Predicted to enable sarcosine dehydrogenase activity. Involved in S-adenosylmethionine cycle and sarcosine catabolic process. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sardh in Genome Data Viewer
    Location:
    54E8-54E8; 2-84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17753555..17756422, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13641060..13643927, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene HLH54F Neighboring gene acyl-CoA oxidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutritional geometry framework of sleep. Lai ML, et al. Life Sci, 2023 Mar 1. PMID 36640899
    2. Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan. Obata F, et al. Nat Commun, 2015 Sep 18. PMID 26383889, Free PMC Article
    3. Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis. Obata F, et al. Cell Rep, 2014 May 8. PMID 24746817
    4. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article
    5. Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models. Livelo C, et al. Nat Commun, 2023 Feb 21. PMID 36810287, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sarcosine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sarcosine dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sarcosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sarcosine dehydrogenase
    Names
    CG6385-PA
    Sardh-PA
    NP_611263.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17753555..17756422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137419.3 → NP_611263.1  sarcosine dehydrogenase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAZ2, T2FFP0
      Related
      FBpp0088528
      Conserved Domains (7) summary
      COG0404
      Location:446 → 884
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:33 → 412
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam01571
      Location:456 → 767
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:774 → 867
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:398 → 449
      FAO_M; FAD dependent oxidoreductase central domain
      cl00226
      Location:203 → 281
      nuc_hydro; nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal ...
      cl21454
      Location:37 → 76
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAZ2 A1ZAZ2
    Q8IGS5 Q8IGS5
    Q961K2 Q961K2

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