gl glass [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: glprovided by FlyBase
Official Full Name: glassprovided by FlyBase
Primary source: FLYBASE:FBgn0004618
Locus tag: Dmel_CG7672
See related: AllianceGenome:FB:FBgn0004618
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7672; Dmel\CG7672; E(sina)5; Gl; gla; Gla; Glass; none; rh; SS3-2; SY3-3
Summary: Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including circadian temperature homeostasis; entrainment of circadian clock by photoperiod; and ring gland development. Located in nucleus. Is expressed in several structures, including Bolwig organ primordium; brain; cell cluster organ; imaginal disc; and pigment cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 91A3-91A3; 3-63 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18367927..18372738, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14193649..14198460, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the expression of glass is tightly regulated as the development of a functional tissue surprisingly does not result in detectable change in the physiological response or alteration in photo-attraction behavior upon deletion of the smORF. Similarly, only one of the isoforms is critical for eye development.
Title: Multilevel regulation of the glass locus during Drosophila eye development.
Glass is a determinant of organ identity that acts in both neuronal and non-neuronal cells to promote their differentiation into functional components of the eye.
Title: Glass promotes the differentiation of neuronal and non-neuronal cell types in the Drosophila eye.
Authors conclude that Glass can either directly or indirectly initiate the expression of most phototransduction proteins in a Hazy-independent manner, and that Hazy is mainly required for the maintenance of functional photoreceptors in adult flies.
Title: Successive requirement of Glass and Hazy for photoreceptor specification and maintenance in Drosophila.
Glass has a dual role in establishing a functional Drosophila eye. Glass links photoreceptor specification/patterning and terminal differentiation. Glass mutant photoreceptors are capable of surviving pupal development but fail to differentiate. The role of Glass in ommatidium patterning and photoreceptor differentiation are separable. Pph13 is its direct transcriptional target. * Pph13 is a direct transcriptional target
Title: Two temporal functions of Glass: Ommatidium patterning and photoreceptor differentiation.
photoreceptor cell identity in Drosophila is critically regulated by the transcription factor Glass
Title: The transcription factor Glass links eye field specification with photoreceptor differentiation in Drosophila.
Results describe the roles of sine oculis and glass proteins in the development of the Drosophila corpus cardiacum.
Title: Embryonic development of the Drosophila corpus cardiacum, a neuroendocrine gland with similarity to the vertebrate pituitary, is controlled by sine oculis and glass.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in circadian temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to red light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ring gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glass

Names: CG7672-PA; CG7672-PB; CG7672-PC; GLASS; enhancer of seven in absentia 5; gl-PA; gl-PB; gl-PC; no-ocelli--narrow-eyes; rauhig; suppressor of GMR-sina 3-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18367927..18372738 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057506.3 → NP_476854.1 glass, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476854.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13360, Q95T58, Q9VE83, Q9VE84

Related

FBpp0083005

Conserved Domains (4) summary

sd00017
Location:467 → 487

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:439 → 459

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:452 → 476

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:492 → 570

zf-C2H2_8; C2H2-type zinc ribbon
NM_001275779.1 → NP_001262708.1 glass, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262708.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGX3

Conserved Domains (4) summary

sd00017
Location:467 → 487

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:439 → 459

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:452 → 476

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:492 → 570

zf-C2H2_8; C2H2-type zinc ribbon
NM_169807.4 → NP_732330.1 glass, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732330.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13360

Related

FBpp0083006

Conserved Domains (4) summary

sd00017
Location:467 → 487

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:521 → 543

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:452 → 476

zf-H2C2_2; Zinc-finger double domain

pfam15909
Location:464 → 544

zf-C2H2_8; C2H2-type zinc ribbon