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    Orct Organic cation transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42891, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orctprovided by FlyBase
    Official Full Name
    Organic cation transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0019952
    Locus tag
    Dmel_CG6331
    See related
    AllianceGenome:FB:FBgn0019952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6331; Dmel\CG6331; orct; SLC22A5; SLC22A5/13
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in apoptotic process. Predicted to be located in membrane. Is expressed in several structures, including adult head; amnioserosa; ganglia; gut section; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; acute kidney failure; cardiomyopathy; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A13 (solute carrier family 22 member 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Orct in Genome Data Viewer
    Location:
    95F8-95F8; 3-84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24276260..24278792)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20101982..20104514)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene jaguar Neighboring gene transfer RNA:Leucine-TAA 4-1 Neighboring gene Organic cation transporter 2 Neighboring gene long non-coding RNA:CR45662 Neighboring gene sheepish

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Orct gene of Drosophila melanogaster codes for a putative organic cation transporter with six or 12 transmembrane domains. Taylor CA, et al. Gene, 1997 Nov 12. PMID 9409773
    2. Drosophila SLC22A Transporter Is a Memory Suppressor Gene that Influences Cholinergic Neurotransmission to the Mushroom Bodies. Gai Y, et al. Neuron, 2016 May 4. PMID 27146270, Free PMC Article
    3. Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier. Li F, et al. Elife, 2023 May 4. PMID 37140181, Free PMC Article
    4. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
    5. Hsp27 over expression protect against cadmium induced nephrotoxicity in Drosophila melanogaster. Saini S, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2023 Nov. PMID 37586579

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    organic cation transporter
    Names
    CG6331-PA
    CG6331-PB
    Orct-PA
    Orct-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24276260..24278792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079755.2 → NP_524479.1  organic cation transporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524479.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01383, O01384, Q9VCA2
      UniProtKB/TrEMBL
      A0A0B4KI00, R9QRD4
      Related
      FBpp0083983
      Conserved Domains (2) summary
      cd06174
      Location:135 → 491
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 514
      2A0119; cation transport protein

    2. NM_001275979.1 → NP_001262908.1  organic cation transporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01383, O01384, Q9VCA2
      UniProtKB/TrEMBL
      A0A0B4KI00, R9QRD4
      Conserved Domains (2) summary
      cd06174
      Location:135 → 491
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11 → 514
      2A0119; cation transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI00 A0A0B4KI00
    Q9VCA2.1 Q9VCA2

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