Ace Acetylcholine esterase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Aceprovided by FlyBase
Official Full Name: Acetylcholine esteraseprovided by FlyBase
Primary source: FLYBASE:FBgn0000024
Locus tag: Dmel_CG17907
See related: AllianceGenome:FB:FBgn0000024
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AcChE; ace; ACE; ace-2; ache; AchE; AChE; ACHE; CG17907; ChE; CHE; dAChE; dmAChE; DmAChE; Dmel\CG17907; Dm_ace; l(3)26; l(3)87Ed
Summary: Enables acetylcholinesterase activity; protein homodimerization activity; and sulfate binding activity. Involved in acetylcholine catabolic process; chemical synaptic transmission; and choline catabolic process. Located in cytoplasm and plasma membrane. Is expressed in adult head; embryonic brain; embryonic central brain neurons; larval ventral nerve cord; and lateral cord neurons. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); drug dependence (multiple); myasthenia gravis; and subacute delirium. Orthologous to several human genes including BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87E2-87E3; 3-53 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13222951..13259517, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9048673..9085239, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional characterisation of the ACE2 orthologues in Drosophila provides insights into the neuromuscular complications of COVID-19.
Title: Functional characterisation of the ACE2 orthologues in Drosophila provides insights into the neuromuscular complications of COVID-19.
molecular dynamics simulation reveals the insecticidal resistance mechanism of AChE and its mutation
Title: A butterfly effect: highly insecticidal resistance caused by only a conservative residue mutated of drosophila melanogaster acetylcholinesterase.
Results provide insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge.
Title: Insights into substrate and product traffic in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel.
kinetic studies show that it affects interactions with peripheral ligands and the entrance of some of the bulkier substrates
Title: Evidence for subdomain flexibility in Drosophila melanogaster acetylcholinesterase.
1 engineered disulfide bridge, I327C/D375C increased stability to heat denaturation, urea, & organic solvents & provided protease resistance. The new disulfide bridge links the N-terminal domain (first 356 aa) to the C-terminal domain.
Title: The effect of engineered disulfide bonds on the stability of Drosophila melanogaster acetylcholinesterase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetylcholinesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholinesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholinesterase activity	IEA Inferred from Electronic Annotation more info
enables acetylcholinesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cholinesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables cholinesterase activity	IEA Inferred from Electronic Annotation more info
NOT enables peptidase activity	IKR Inferred from Key Residues more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables serine hydrolase activity	HDA more info	PubMed
enables sulfate binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acetylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetylcholine catabolic process in synaptic cleft	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in choline catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in choline metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acetylcholine esterase

Names: Ace-PA; Ace-PB; Ace-PC; CG17907-PA; CG17907-PB; CG17907-PC; acetyl choline esterase; acetylcholinesterase; cholinesterase

NP_001163600.1

EC 3.1.1.7

EC 3.1.1.8

NP_001262530.1

EC 3.1.1.7

EC 3.1.1.8

NP_476953.1

EC 3.1.1.7

EC 3.1.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13222951..13259517 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275601.1 → NP_001262530.1 acetylcholine esterase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262530.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P07140, Q9VFY0

UniProtKB/TrEMBL

A0A0B4KGI5

Conserved Domains (1) summary

pfam00135
Location:41 → 601

COesterase; Carboxylesterase family
NM_057605.5 → NP_476953.1 acetylcholine esterase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476953.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P07140, Q9VFY0

UniProtKB/TrEMBL

E1JIJ8

Related

FBpp0082248

Conserved Domains (1) summary

pfam00135
Location:41 → 601

COesterase; Carboxylesterase family
NM_001170129.2 → NP_001163600.1 acetylcholine esterase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163600.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P07140, Q9VFY0

UniProtKB/TrEMBL

E1JIJ8

Conserved Domains (1) summary

pfam00135
Location:41 → 601

COesterase; Carboxylesterase family