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    Capa Capability [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43541, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Capaprovided by FlyBase
    Official Full Name
    Capabilityprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039722
    Locus tag
    Dmel_CG15520
    See related
    AllianceGenome:FB:FBgn0039722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAP; Cap-1; Cap-2; Cap-2b; CAP-2b; Cap-3; CAP2b; CAP2b-1; CAP2B-1; CAP2b-2; CAP2B-2; CAP2b-3; CAP2B-3; CAP2B/pyrokinin; capa; CAPA; capa 2; capa-1; Capa-1; capa-2; Capa-2; capa-3; Capa-PK; CAPA-PK; CAPA-PVK-1; CAPA-PVK-2; CAPA-PVK/PK; CAP[[2b]]; CG15520; CPPB; Dmel\CG15520; Drm-CAP-1; Drm-CAP-2; Drm-CAP2b/MT; Drm-capa-1; Drm-MT; Drm-PK; Drm-PK-1; Drm-PVK; Drm-PVK-1; Drm-PVK-2; Drome-capa-1; PVK-2; pyrokinin/PBAN-like
    Summary
    Enables hormone activity and neuropeptide receptor binding activity. Involved in several processes, including epithelial fluid transport; neuropeptide signaling pathway; and nitric oxide-cGMP-mediated signaling. Located in extracellular space. Is expressed in Malpighian tubule; Va neurons; larval central nervous system; larval subesophageal capability neurons; and ventral group vA neuron. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Capa in Genome Data Viewer
    Location:
    99C6-99C6; 3-99 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29912991..29914346, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25738713..25740068, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transient receptor potential Neighboring gene Jonah 99Ciii

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CAP2b, a cardioacceleratory peptide, is present in Drosophila and stimulates tubule fluid secretion via cGMP. Davies SA, et al. Am J Physiol, 1995 Dec. PMID 8594932
    2. The periviscerokinin (PVK) peptide family in insects: evidence for the inclusion of CAP(2b) as a PVK family member. Wegener C, et al. Peptides, 2002 Apr. PMID 11897378
    3. Neuropeptide stimulation of the nitric oxide signaling pathway in Drosophila melanogaster Malpighian tubules. Davies SA, et al. Am J Physiol, 1997 Aug. PMID 9277574
    4. Signaling by Drosophila capa neuropeptides. Davies SA, et al. Gen Comp Endocrinol, 2013 Jul 1. PMID 23557645
    5. The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. MacPherson MR, et al. J Exp Biol, 2004 Jul. PMID 15235005

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila.
      Title: A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila.
    2. This study provides evidence that low (femtomolar) and high (micromolar) doses of CAPA impair and improve chill tolerance, respectively, via two different effects on Malpighian tubule ion and water transport. While low doses of CAPA are anti-diuretic, reduce tubule K(+) clearance rates and reduce chill tolerance, high doses facilitate K(+) clearance from the haemolymph and increase chill tolerance.
      Title: Anti-diuretic activity of a CAPA neuropeptide can compromise Drosophila chill tolerance.
    3. Va-A1 neurons terminally differentiate into DH31/AstA-expressing neurons (neuropeptidergic fate I) by virtue of Ubx activity, and Va-A2-A4 neurons terminally differentiate into Capa-expressing neurons
      Title: Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system.
    4. regulation of cellular ion and water homeostasis mediated by capa peptide signaling in the insect Malpighian (renal) tubules is a key physiological mechanism during recovery from desiccation and cold stress.
      Title: Insect capa neuropeptides impact desiccation and cold tolerance.
    5. Developmental appearance of the peptidergic, Capability-expressing Va neurons
      Title: Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues.
    6. 99D on chromosome 3R potentially encodes GANMGLYAFPRV-amide (capa-1), ASGLVAFPRV-amide (capa-2), and TGPSASSGLWGPRL-amide (capa-3). neuroendocrine cells release capa peptides into hemolymph
      Title: Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster.
    7. cloning and expression of a receptor for capa-1 and capa-2 in Drosophila
      Title: Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables diuretic hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myostimulatory hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables neuropeptide hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables neuropeptide receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epithelial fluid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitric oxide-cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    capability
    Names
    CAP
    CAP2B-like
    CG15520-PA
    Capa-PA
    Drm-myotropin
    TGPSASSGLWFGPRLamide
    cardio acceleratory peptide
    cardioacceleratory peptide-2b
    myotropin
    myotropin-CAP2b-like
    periviscerokinin
    pyrokinin
    pyrokinin-1
    pyrokinin-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29912991..29914346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079828.3 → NP_524552.1  capability [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524552.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NIP6, Q9VAE2
      UniProtKB/TrEMBL
      A0A1B2AIW9
      Related
      FBpp0084880
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NIP6.1 Q9NIP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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