cl clot [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: clprovided by FlyBase
Official Full Name: clotprovided by FlyBase
Primary source: FLYBASE:FBgn0000318
Locus tag: Dmel_CG11024
See related: AllianceGenome:FB:FBgn0000318
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE06767; CG11024; Dmel\CG11024
Summary: Predicted to enable protein-disulfide reductase (NAD(P)H) activity. Involved in eye pigment biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior endoderm anlage; embryonic proventriculus inner layer; gut section; mesoderm; and posterior endoderm. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 25E5-25E5; 2-17 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (5520135..5521382)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (5520135..5521382)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clot protein is an essential component of a glutathione redox system required for the final step in the biosynthetic pathway for drosopterins. Cloning, molecular organization and sequence alterations associated with the alleles cl(1) and cl(2)
Title: The clot gene of Drosophila melanogaster encodes a conserved member of the thioredoxin-like protein superfamily.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein-disulfide reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase (NAD(P)H) activity	IEA Inferred from Electronic Annotation more info
enables protein-disulfide reductase (NAD(P)H) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in eye pigment biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: clot

Names: CG11024-PA; CG11024-PB; CG11024-PC; cl-PA; cl-PB; cl-PC

NP_001260098.1

EC 1.8.1.8

NP_001260099.1

EC 1.8.1.8

NP_608930.1

EC 1.8.1.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

5520135..5521382

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273169.1 → NP_001260098.1 clot, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260098.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VMQ9

Conserved Domains (1) summary

pfam06110
Location:6 → 124

DUF953; Eukaryotic protein of unknown function (DUF953)
NM_001273170.1 → NP_001260099.1 clot, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260099.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VMQ9

Conserved Domains (1) summary

pfam06110
Location:6 → 124

DUF953; Eukaryotic protein of unknown function (DUF953)
NM_135086.4 → NP_608930.1 clot, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608930.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VMQ9

Related

FBpp0078728

Conserved Domains (1) summary

pfam06110
Location:6 → 124

DUF953; Eukaryotic protein of unknown function (DUF953)