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    Cep97 Centrosomal protein 97kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33610, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep97provided by FlyBase
    Official Full Name
    Centrosomal protein 97kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031575
    Locus tag
    Dmel_CG3980
    See related
    AllianceGenome:FB:FBgn0031575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cep97; CG3980; CT13231; DCep97; Dmel\CG3980
    Summary
    Involved in centriole elongation. Located in centriole and pericentriolar material. Orthologous to human CEP97 (centrosomal protein 97). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cep97 in Genome Data Viewer
    Location:
    24C8-24C8; 2-11 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3867697..3871425)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3867697..3871425)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44078 Neighboring gene Tubulin tyrosine ligase-like 4B Neighboring gene uncharacterized protein Neighboring gene cappuccino Neighboring gene friend of echinoid Neighboring gene Folylpolyglutamate synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cep104 is a component of the centriole distal tip complex that regulates centriole growth and contributes to Drosophila spermiogenesis. Ryniawec JM, et al. Curr Biol, 2023 Oct 9. PMID 37729913, Free PMC Article
    2. Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal end. Aydogan MG, et al. J Cell Sci, 2022 Jul 15. PMID 35707992, Free PMC Article
    3. Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation. Dzhindzhev NS, et al. Curr Biol, 2014 Nov 3. PMID 25264260, Free PMC Article
    4. Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila. Dobbelaere J, et al. Curr Biol, 2020 Aug 3. PMID 32589908
    5. Dysregulated glial genes in Alzheimer's disease are essential for homeostatic plasticity: Evidence from integrative epigenetic and single cell analyses. Cai Y, et al. Aging Cell, 2023 Nov. PMID 37712202, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila.
      Title: Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in centriole elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centrosomal protein 97kDa
    Names
    CG3980-PB
    CG3980-PD
    Cep97-PB
    Cep97-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3867697..3871425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134967.4 → NP_608811.2  centrosomal protein 97kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608811.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q45EX7, Q9VQV7
      Conserved Domains (5) summary
      smart00015
      Location:581 → 599
      IQ; Calmodulin-binding motif
      cd00116
      Location:49 → 189
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:11 → 31
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:76 → 115
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:97 → 152
      LRR_8; Leucine rich repeat

    2. NM_001169396.1 → NP_001162867.1  centrosomal protein 97kDa, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHS8
      Conserved Domains (1) summary
      smart00015
      Location:81 → 99
      IQ; Calmodulin-binding motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHS8 E1JHS8
    Q9VQV7 Q9VQV7

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