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    Spps Sp1-like factor for pairing sensitive-silencing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sppsprovided by FlyBase
    Official Full Name
    Sp1-like factor for pairing sensitive-silencingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039169
    Locus tag
    Dmel_CG5669
    See related
    AllianceGenome:FB:FBgn0039169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5669; Dmel\CG5669
    Summary
    Enables sequence-specific DNA binding activity. Involved in heterochromatin formation. Located in nucleus and polytene chromosome band. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP1 (Sp1 transcription factor); SP3 (Sp3 transcription factor); and SP4 (Sp4 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spps in Genome Data Viewer
    Location:
    95F2-95F3; 3-84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24223445..24226934, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20049167..20052656, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene twin Neighboring gene uncharacterized protein Neighboring gene caravaggio Neighboring gene Spase 22/23-subunit Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 95EF

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global changes of H3K27me3 domains and Polycomb group protein distribution in the absence of recruiters Spps or Pho. Brown JL, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432187, Free PMC Article
    2. The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo. Gubala AM, et al. Mol Biol Evol, 2017 May 1. PMID 28104747, Free PMC Article
    3. Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development. Brown JL, et al. Development, 2010 Aug 1. PMID 20627963, Free PMC Article
    4. A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location. Schaeper ND, et al. BMC Evol Biol, 2010 Mar 30. PMID 20353601, Free PMC Article
    5. Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila. Brown JL, et al. Genetics, 2023 Aug 9. PMID 37216193, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development
      Title: Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sp1-like factor for pairing sensitive-silencing
    Names
    CG5669-PA
    CG5669-PB
    Sp1-like factor for pairing Sensitive-silencing
    Spps-PA
    Spps-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24223445..24226934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142975.3 → NP_651232.1  Sp1-like factor for pairing sensitive-silencing, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651232.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XXX8, Q9VCB2
      Related
      FBpp0083950
      Conserved Domains (5) summary
      COG5651
      Location:33 → 266
      COG5651; PPE-repeat protein [Function unknown]
      sd00017
      Location:742 → 764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:800 → 822
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:786 → 809
      zf-H2C2_2; Zinc-finger double domain
      cl41773
      Location:281 → 371
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    2. NM_001275973.1 → NP_001262902.1  Sp1-like factor for pairing sensitive-silencing, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHC8, Q2XXX8
      Conserved Domains (4) summary
      COG5048
      Location:725 → 827
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:742 → 764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:800 → 822
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:786 → 809
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHC8 A0A0B4KHC8
    Q2XXX8 Q2XXX8
    Q9VCB2 Q9VCB2

    Gene LinkOut

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