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    Sse Separase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sseprovided by FlyBase
    Official Full Name
    Separaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035627
    Locus tag
    Dmel_CG10583
    See related
    AllianceGenome:FB:FBgn0035627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10583; Dmel\CG10583; l(3)13m-281; l(3)SG14; sse; SSE
    Summary
    Enables cysteine-type endopeptidase activity. Involved in meiotic chromosome separation; mitotic sister chromatid segregation; and telomere capping. Located in chromosome, telomeric repeat region. Is expressed in organism. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sse in Genome Data Viewer
    Location:
    64E1-64E1; 3-15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5659700..5662247, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5652800..5655347, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Blimp-1 Neighboring gene lin-28 Neighboring gene uncharacterized protein Neighboring gene still life Neighboring gene uncharacterized protein Neighboring gene DnaJ-like-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shugoshin and PP2A, shared duties at the centromere. Rivera T, et al. Bioessays, 2006 Aug. PMID 16927389
    2. Separase: a conserved protease separating more than just sisters. Ross KE, et al. Trends Cell Biol, 2002 Jan. PMID 11853993
    3. Chromosome cohesion and separation: from men and molecules. Uhlmann F. Curr Biol, 2003 Feb 4. PMID 12573239
    4. Regulating sister chromatid separation by separase phosphorylation. Nagao K, et al. Dev Cell, 2002 Jan. PMID 11782307
    5. Role of Securin, Separase and Cohesins in female meiosis and polar body formation in Drosophila. Guo Z, et al. J Cell Sci, 2016 Feb 1. PMID 26675236

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromosome separation during Drosophila male meiosis I requires separase-mediated cleavage of the homolog conjunction protein UNO.
      Title: Chromosome separation during Drosophila male meiosis I requires separase-mediated cleavage of the homolog conjunction protein UNO.
    2. This paper demonstrates that separase, a protease that separates canonical bivalents by cleavage of a cohesin subunit, is also required during male meiosis I, even though alternative homolog conjunction does not depend on cohesin.
      Title: Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres.
    3. genetic loci that modify the aberrant phenotypes caused by overexpression of the regulatory separase complex subunits
      Title: Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog.
    4. Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.
      Title: Proteolytic cleavage of the THR subunit during anaphase limits Drosophila separase function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic chromosome separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    separase
    Names
    CG10583-PA
    Sse-PA
    lethal(3)SG14
    NP_523935.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5659700..5662247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079211.3 → NP_523935.1  separase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRN6
      Related
      FBpp0076831
      Conserved Domains (1) summary
      pfam03568
      Location:171 → 538
      Peptidase_C50; Peptidase family C50
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRN6 Q9VRN6

    Gene LinkOut

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