U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Elp6 Elongator complex protein 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41641, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Elp6provided by FlyBase
    Official Full Name
    Elongator complex protein 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0086371
    Locus tag
    Dmel_CG9829
    See related
    AllianceGenome:FB:FBgn0086371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0081/31; CG9829; did; did/alt1; Dmel\CG9829; l(3)05137; l(3)S008131; poly
    Summary
    Enables insulin receptor binding activity. Involved in melanotic encapsulation of foreign target; microtubule cytoskeleton organization; and positive regulation of insulin receptor signaling pathway. Part of elongator holoenzyme complex. Orthologous to human ELP6 (elongator acetyltransferase complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Elp6 in Genome Data Viewer
    Location:
    87E7-87E8; 3-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13361816..13366910, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9187538..9192632, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pyrokinin 2 receptor 1 Neighboring gene methuselah-like 12 Neighboring gene Dicarboxylate carrier 1 Neighboring gene Chemosensory protein A 87a Neighboring gene Lipase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. poly is required for nurse-cell chromosome dispersal and oocyte polarity in Drosophila. Klusza S, et al. Fly (Austin), 2010 Apr-Jun. PMID 20473032, Free PMC Article
    2. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
    3. Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Bolukbasi E, et al. Open Biol, 2012 Jan. PMID 22645656, Free PMC Article
    4. Dissection of Complex, Fitness-Related Traits in Multiple Drosophila Mapping Populations Offers Insight into the Genetic Control of Stress Resistance. Everman ER, et al. Genetics, 2019 Apr. PMID 30760490, Free PMC Article
    5. Proper CycE-Cdk2 activity in endocycling tissues requires regulation of the cyclin-dependent kinase inhibitor Dacapo by dE2F1b in Drosophila. Kim M, et al. Genetics, 2021 Mar 3. PMID 33683365, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables insulin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of mitotic spindle asymmetry IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton polarization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    elongator complex protein 6
    Names
    CG9829-PA
    CG9829-PB
    Elp6-PA
    Elp6-PB
    lethal (3) 05137
    poly

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13361816..13366910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202286.1 → NP_001189215.1  elongator complex protein 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189215.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NH01, Q9VFW4
      UniProtKB/TrEMBL
      Q6NP11
      Conserved Domains (1) summary
      pfam09807
      Location:26 → 236
      ELP6; Elongation complex protein 6

    2. NM_079619.4 → NP_524343.2  elongator complex protein 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524343.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NH01, Q9VFW4
      UniProtKB/TrEMBL
      Q6NP11
      Related
      FBpp0082240
      Conserved Domains (1) summary
      pfam09807
      Location:26 → 236
      ELP6; Elongation complex protein 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NH01 Q9NH01
    Q9VFW4 Q9VFW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools