Idua alpha-L-iduronidase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Iduaprovided by FlyBase
Official Full Name: alpha-L-iduronidaseprovided by FlyBase
Primary source: FLYBASE:FBgn0032343
Locus tag: Dmel_CG6201
See related: AllianceGenome:FB:FBgn0032343
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6201; D-idua; Dmel\CG6201; IDUA
Summary: Enables L-iduronidase activity. Predicted to be involved in glycosaminoglycan catabolic process. Predicted to be located in lysosome. Is expressed in larval MP1 neuron and larval midline neurons. Used to study mucopolysaccharidosis I. Human ortholog(s) of this gene implicated in Scheie syndrome; mucopolysaccharidosis I; mucopolysaccharidosis Ih; and mucopolysaccharidosis Ih/s. Orthologous to human IDUA (alpha-L-iduronidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (11110557..11113061, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (11110557..11113061, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila D-idua Reduction Mimics Mucopolysaccharidosis Type I Disease-Related Phenotypes.
Title: Drosophila D-idua Reduction Mimics Mucopolysaccharidosis Type I Disease-Related Phenotypes.

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Function	Evidence Code	Pubs
enables L-iduronidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-iduronidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycosaminoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info

NP_609489.1

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The following sections contain reference sequences that belong to a specific genome build. Explain