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    pim pimples [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pimprovided by FlyBase
    Official Full Name
    pimplesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003087
    Locus tag
    Dmel_CG5052
    See related
    AllianceGenome:FB:FBgn0003087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5052; Dmel\CG5052; frag2; l(2)31Df; Pim; PIM; sec
    Summary
    Involved in digestive tract development; gonad development; and mitotic sister chromatid separation. Located in cytoplasm. Is expressed in several structures, including central brain primordium; ganglia; presumptive embryonic/larval central nervous system; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pim in Genome Data Viewer
    Location:
    31D10-31D10; 2-41 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10362989..10364092)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10362989..10364092)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Caseinolytic protease proteolytic subunit Neighboring gene Cullin-associated and neddylation-dissociated 1 Neighboring gene lowfat Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The making and breaking of sister chromatid cohesion. Cohen-Fix O. Cell, 2001 Jul 27. PMID 11511341
    2. Separase: a conserved protease separating more than just sisters. Ross KE, et al. Trends Cell Biol, 2002 Jan. PMID 11853993
    3. Chromosome changes in cell differentiation. Miller OJ. Genetics, 1997 May. PMID 9135996, Free PMC Article
    4. Role of Securin, Separase and Cohesins in female meiosis and polar body formation in Drosophila. Guo Z, et al. J Cell Sci, 2016 Feb 1. PMID 26675236
    5. Sister chromatid cohesion in mitosis. Biggins S, et al. Curr Opin Genet Dev, 1999 Apr. PMID 10322145

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effects of the stabilized securin PIM with mutations in the D-box are enhanced in vivo by reduced Polo kinase function or by mitotically stabilized Cyclin A.
      Title: Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in digestive tract mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pimples
    Names
    CG5052-PA
    CG5052-PB
    PIMPLES
    fragmented gonads 2
    pim-PA
    pim-PB
    securin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10362989..10364092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273405.1 → NP_001260334.1  pimples, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24454
      Conserved Domains (1) summary
      pfam04856
      Location:1 → 188
      Securin; Securin sister-chromatid separation inhibitor

    2. NM_057330.3 → NP_476678.1  pimples, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24454
      Related
      FBpp0079591
      Conserved Domains (1) summary
      pfam04856
      Location:1 → 188
      Securin; Securin sister-chromatid separation inhibitor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24454 Q24454

    Gene LinkOut

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