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    Lst8 Lst8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lst8provided by FlyBase
    Official Full Name
    Lst8provided by FlyBase
    Primary source
    FLYBASE:FBgn0264691
    Locus tag
    Dmel_CG3004
    See related
    AllianceGenome:FB:FBgn0264691
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3004; dGbetaL; dLST8; Dmel\CG3004; Gbl; lst8; LST8
    Summary
    Involved in several processes, including TORC2 signaling; positive regulation of cell size; and positive regulation of signal transduction. Part of TORC2 complex. Is expressed in adult head. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lst8 in Genome Data Viewer
    Location:
    8F1-8F1; 1-29 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9604154..9605969, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9498187..9500002, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45542 Neighboring gene long non-coding RNA:CR45543 Neighboring gene Golgi-localized, gamma-adaptin ear containing, ARF binding protein Neighboring gene Lysyl-tRNA synthetase Neighboring gene Hecw ubiquitin protein ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionarily conserved regulation of TOR signalling. Takahara T, et al. J Biochem, 2013 Jul. PMID 23698095
    2. Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila. Kuo Y, et al. Sci Rep, 2015 May 22. PMID 25999153, Free PMC Article
    3. GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila. Frappaolo A, et al. Cell Death Dis, 2022 Nov 27. PMID 36435842, Free PMC Article
    4. Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR. Erdogan CS, et al. Mech Ageing Dev, 2016 Jan. PMID 26763146
    5. Loss of miR-34 in Drosophila dysregulates protein translation and protein turnover in the aging brain. Srinivasan AR, et al. Aging Cell, 2022 Mar. PMID 35166006, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by transcription factor localization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein localization to nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    NOT part_of TORC1 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TORC2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Lst8
    Names
    CG3004-PA
    Lst8-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9604154..9605969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132344.4 → NP_572572.1  Lst8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572572.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RK5, Q9W328
      UniProtKB/TrEMBL
      B4F5L6
      Related
      FBpp0071303
      Conserved Domains (3) summary
      COG2319
      Location:3 → 306
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8 → 284
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:41 → 78
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W328.2 Q9W328

    Gene LinkOut

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