loj logjam [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: lojprovided by FlyBase
Official Full Name: logjamprovided by FlyBase
Primary source: FLYBASE:FBgn0061492
Locus tag: Dmel_CG10733
See related: AllianceGenome:FB:FBgn0061492
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10733; Dmel\CG10733; l(3)04026; Loj; LOJ; p24
Summary: Predicted to enable cargo receptor activity. Involved in egg-laying behavior. Located in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including adult brain; adult fat body; adult head; adult ventral nerve cord; and gland. Orthologous to human TMED6 (transmembrane p24 trafficking protein 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6094987..6096517)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6088087..6089617)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

20% of the loci up regulated in loj mutants are immune-regulated genes, many of which are transcriptional targets of NF-kappaB or JNK signaling pathways.
Title: Loss of p24 function in Drosophila melanogaster causes a stress response and increased levels of NF-kappaB-regulated gene products.
Logjam (loj), is expressed in the adult female nervous system and ovaries and is essential for oviposition.
Title: Drosophila melanogaster p24 genes have developmental, tissue-specific, and sex-specific expression patterns and functions.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cargo receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi vesicle transport	ISM Inferred from Sequence Model more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain