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    CG7878 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7878provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037549
    Locus tag
    Dmel_CG7878
    See related
    AllianceGenome:FB:FBgn0037549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7878; Dmel\CG7878; DmRH26
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Is expressed in adult head; germline cell; gonad; and organism. Orthologous to human DDX43 (DEAD-box helicase 43) and DDX53 (DEAD-box helicase 53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7878 in Genome Data Viewer
    Location:
    84E13-84E13; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8122725..8125273)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3948447..3950995)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene puckered Neighboring gene long non-coding RNA:CR44331 Neighboring gene uncharacterized protein Neighboring gene ADP ribosylation factor-like 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article
    2. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Moy RH, et al. Cell, 2014 Aug 14. PMID 25126784, Free PMC Article
    3. Evolution of intron/exon structure of DEAD helicase family genes in Arabidopsis, Caenorhabditis, and Drosophila. Boudet N, et al. Genome Res, 2001 Dec. PMID 11731501, Free PMC Article
    4. RNA silencing in the antiviral innate immune defence--role of DEAD-box RNA helicases. Ulvila J, et al. Scand J Immunol, 2010 Mar. PMID 20415780
    5. Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila. Curnutte HA, et al. Cell Rep, 2023 Jul 25. PMID 37384531, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7878-PA
    NP_649767.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8122725..8125273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141510.4 → NP_649767.1  uncharacterized protein Dmel_CG7878 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4L8
      Related
      FBpp0112117
      Conserved Domains (4) summary
      smart00487
      Location:298 → 505
      DEXDc; DEAD-like helicases superfamily
      cd00105
      Location:92 → 150
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd00268
      Location:288 → 489
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:514 → 624
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4L8 Q7K4L8

    Gene LinkOut

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