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    Tcs4 Threonyl-carbamoyl synthesis 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcs4provided by FlyBase
    Official Full Name
    Threonyl-carbamoyl synthesis 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0031060
    Locus tag
    Dmel_CG14231
    See related
    AllianceGenome:FB:FBgn0031060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14231; Dmel\CG14231
    Summary
    Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity. Predicted to be involved in mitochondrial tRNA threonylcarbamoyladenosine modification. Predicted to be active in mitochondrial matrix. Orthologous to human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tcs4 in Genome Data Viewer
    Location:
    18E1-18E1; 1-64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19699820..19701755, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19593853..19595788, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Merlin Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 42 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene meso18E Neighboring gene long non-coding RNA:CR44889

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA. Thiaville PC, et al. RNA Biol, 2014. PMID 25629598, Free PMC Article
    2. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article
    3. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Jimenez-Sanchez M, et al. Nat Chem Biol, 2015 May. PMID 25848931, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N(6)-L-threonylcarbamoyladenine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA threonylcarbamoyladenosine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Threonyl-carbamoyl synthesis 4
    Names
    CG14231-PA
    CG14231-PB
    Tcs4-PA
    Tcs4-PB
    tRNA adenosine(37) threonylcarbamoyltransferase, mitochondrial
    NP_001245765.1
    NP_608347.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19699820..19701755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258836.2 → NP_001245765.1  Threonyl-carbamoyl synthesis 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245765.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960S6, Q9VWD6
      UniProtKB/TrEMBL
      M9NHD5
      Conserved Domains (2) summary
      TIGR03723
      Location:27 → 365
      T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD
      cl22532
      Location:27 → 156
      Carbam_trans_N; Carbamoyltransferase N-terminus

    2. NM_134503.4 → NP_608347.1  Threonyl-carbamoyl synthesis 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608347.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960S6, Q9VWD6
      UniProtKB/TrEMBL
      M9NHD5
      Related
      FBpp0074583
      Conserved Domains (2) summary
      TIGR03723
      Location:27 → 365
      T6A_TsaD_YgjD; tRNA threonylcarbamoyl adenosine modification protein TsaD
      cl22532
      Location:27 → 156
      Carbam_trans_N; Carbamoyltransferase N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NHD5 M9NHD5
    Q9VWD6.1 Q9VWD6

    Gene LinkOut

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