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    CG3165 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33503, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3165provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031484
    Locus tag
    Dmel_CG3165
    See related
    AllianceGenome:FB:FBgn0031484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3165; TREX
    Summary
    Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA catabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus. Orthologous to several human genes including TREX1 (three prime repair exonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3165 in Genome Data Viewer
    Location:
    23C4-23C4; 2-8 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2977122..2978500)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2977122..2978500)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene gamma-Tubulin at 23C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chromodomain-helicase-DNA-binding protein 1 Neighboring gene Bem46 Neighboring gene okra

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila heart optical coherence microscopy dataset for automatic video segmentation. Fishman M, et al. Sci Data, 2023 Dec 9. PMID 38071220, Free PMC Article
    2. Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Chauvin SD, et al. Nat Commun, 2024 Jun 1. PMID 38824133, Free PMC Article
    3. CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo. Konev AY, et al. Science, 2007 Aug 24. PMID 17717186, Free PMC Article
    4. Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. Axelsson E, et al. BMC Bioinformatics, 2011 Aug 17. PMID 21849035, Free PMC Article
    5. Evidence for large domains of similarly expressed genes in the Drosophila genome. Spellman PT, et al. J Biol, 2002. PMID 12144710, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans.
      Title: Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-5'-DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3165-PA
    CG3165-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2977122..2978500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134888.4 → NP_608732.1  uncharacterized protein Dmel_CG3165, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQJ7
      Related
      FBpp0077327
      Conserved Domains (2) summary
      cd06136
      Location:20 → 173
      TREX1_2; DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins
      COG0847
      Location:19 → 155
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]

    2. NM_001298642.1 → NP_001285571.1  uncharacterized protein Dmel_CG3165, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQJ7
      Conserved Domains (2) summary
      cd06136
      Location:20 → 173
      TREX1_2; DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins
      COG0847
      Location:19 → 155
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQJ7 Q9VQJ7

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