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    IMP21 Imp21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854652, updated on 27-Dec-2024

    Summary

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    Official Symbol
    IMP21
    Official Full Name
    Imp21p
    Primary source
    SGD:S000001416
    Locus tag
    YIL154C
    See related
    AllianceGenome:SGD:S000001416; FungiDB:YIL154C; VEuPathDB:YIL154C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    IMP2
    Summary
    Enables transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IMP21 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (53981..55021, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP7 Neighboring gene glycerol-3-phosphate dehydrogenase Neighboring gene peptidylprolyl isomerase RRD1 Neighboring gene Vpr1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. IMP2, a nuclear gene controlling the mitochondrial dependence of galactose, maltose and raffinose utilization in Saccharomyces cerevisiae. Donnini C, et al. Yeast, 1992 Feb. PMID 1561839
    2. IMP2, a gene involved in the expression of glucose-repressible genes in Saccharomyces cerevisiae. Lodi T, et al. Microbiology (Reading), 1995 Sep. PMID 7496532
    3. The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants. Masson JY, et al. Mol Cell Biol, 1996 May. PMID 8628275, Free PMC Article
    4. Isolation and characterization of Saccharomyces cerevisiae mutants with enhanced resistance to the anticancer drug bleomycin. Aouida M, et al. Curr Genet, 2004 May. PMID 15007625
    5. The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae. Masson JY, et al. Genetics, 1998 Jun. PMID 9611200, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAP1 overexpression rescues the imp2Delta mutant from bleomycin toxicity by triggering Tpo1 expression to expel the drug.
      Title: Upregulation of the Saccharomyces cerevisiae efflux pump Tpo1 rescues an Imp2 transcription factor-deficient mutant from bleomycin toxicity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    Imp21p
    NP_012112.3
    • Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      53981..55021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179502.3 → NP_012112.3  TPA: Imp21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012112.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVD3, P32351
      UniProtKB/TrEMBL
      A6ZVC2, B3LU01, B5VKF8, G2WFZ8, N1P0N6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32351.2

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