PDC6 indolepyruvate decarboxylase 6 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PDC6
Official Full Name: indolepyruvate decarboxylase 6
Primary source: SGD:S000003319
Locus tag: YGR087C
See related: AllianceGenome:SGD:S000003319; FungiDB:YGR087C; VEuPathDB:YGR087C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pyruvate decarboxylase activity. Involved in aromatic amino acid family catabolic process and ethanol metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PDC6 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (651290..652981, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables branched-chain-2-oxoacid decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables indolepyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phenylpyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amino acid catabolic process via Ehrlich pathway	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in branched-chain amino acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ethanol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in tryptophan catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: indolepyruvate decarboxylase 6

NP_011601.3

EC 4.1.1.43

EC 4.1.1.72

EC 4.1.1.74

Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

651290..652981 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181216.3 → NP_011601.3 TPA: indolepyruvate decarboxylase 6 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011601.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUL9, P26263

UniProtKB/TrEMBL

A6ZV69, B3LID9, C7GWX6, C8Z8Y1

Conserved Domains (1) summary

COG3961
Location:1 → 563

PDC1; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]