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    LAA1 Laa1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LAA1
    Official Full Name
    Laa1p
    Primary source
    SGD:S000003743
    Locus tag
    YJL207C
    See related
    AllianceGenome:SGD:S000003743; FungiDB:YJL207C; VEuPathDB:YJL207C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein localization and retrograde transport, endosome to Golgi. Acts upstream of or within clathrin-coated vesicle cargo loading, AP-1-mediated. Located in clathrin-coated vesicle. Orthologous to human HEATR5A (HEAT repeat containing 5A) and HEATR5B (HEAT repeat containing 5B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LAA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (41389..47433, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Cbp1p Neighboring gene ribonuclease Neighboring gene uncharacterized protein Neighboring gene Nce101p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast. Zysnarski CJ, et al. J Biol Chem, 2019 Jan 25. PMID 30523155, Free PMC Article
    2. Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast. Fernández GE, et al. Mol Biol Cell, 2006 Jul. PMID 16687571, Free PMC Article
    3. Numerous Post-translational Modifications of RNA Polymerase II Subunit Rpb4/7 Link Transcription to Post-transcriptional Mechanisms. Richard S, et al. Cell Rep, 2021 Jan 12. PMID 33440147
    4. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article
    5. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.
      Title: Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking.
    2. results indicate that Laa2 mediates the interaction between Laa1 and AP-1 and reveal that this interaction promotes the stable association of AP-1 with membranes in yeast
      Title: Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast.
    3. These results identify Laa1p as a new determinant of AP-1 localization, suggesting a model in which Laa1p and Arf cooperate to direct stable association of AP-1 with appropriate intracellular membranes.
      Title: Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within clathrin-coated vesicle cargo loading, AP-1-mediated IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle HDA PubMed 
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Laa1p
    NP_012328.1
    • AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      41389..47433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181640.1 → NP_012328.1  TPA: Laa1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012328.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVY7, P39526
      UniProtKB/TrEMBL
      C8ZB13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39526.1

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