SLT2 mitogen-activated serine/threonine-protein kinase SLT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SLT2
Official Full Name: mitogen-activated serine/threonine-protein kinase SLT2
Primary source: SGD:S000001072
Locus tag: YHR030C
See related: AllianceGenome:SGD:S000001072; FungiDB:YHR030C; VEuPathDB:YHR030C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BYC2; LYT2; MPK1; SLK2
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including intracellular signal transduction; pexophagy; and regulation of fungal-type cell wall organization. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SLT2 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (168890..170344, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases.
Title: Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases.
Hsp90 and phosphorylation of the Slt2(Mpk1) MAP kinase activation loop are essential for catalytic, but not non-catalytic, Slt2-mediated transcription in yeast.
Title: Hsp90 and phosphorylation of the Slt2(Mpk1) MAP kinase activation loop are essential for catalytic, but not non-catalytic, Slt2-mediated transcription in yeast.
The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1.
Title: The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1.
Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2.
Title: Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2.
Signalling through the yeast MAPK Cell Wall Integrity pathway controls P-body assembly upon cell wall stress.
Title: Signalling through the yeast MAPK Cell Wall Integrity pathway controls P-body assembly upon cell wall stress.
TORC1, Tel1/Mec1, and Mpk1 regulate autophagy induction after DNA damage in budding yeast.
Title: TORC1, Tel1/Mec1, and Mpk1 regulate autophagy induction after DNA damage in budding yeast.
Fes1 mutants defective in physical or functional interaction with Hsp70 retained activities that support Vid and cell wall integrity (CWI). Fes1 and the Fes1 mutants bound to the Vid substrate Fbp1 in vitro and captured Slt2, a signaling kinase that regulates CWI, from cell lysates.
Title: Hsp70-nucleotide exchange factor (NEF) Fes1 has non-NEF roles in degradation of gluconeogenic enzymes and cell wall integrity.
This work raises the possibility that other Mpk1-activating stressors act intracellularly at different points along the canonical Mpk1 activation pathway.
Title: Intracellular mechanism by which genotoxic stress activates yeast SAPK Mpk1.
We describe here a role for the yeast MAPK Slt2 as a part of the transcriptional activation machinery necessary for the regulation of Rlm1-dependent genes.
Title: Slt2 MAPK association with chromatin is required for transcriptional activation of Rlm1 dependent genes upon cell wall stress.
Activation of Slt2 by overexpression of a constitutively active allele of an upstream Slt2 activator (Pkc1) or by auxin-induced degradation of a negative Slt2 regulator (Sln1) caused hyperphosphorylation of Avo2 at its MAPK phosphoacceptor sites in a Slt2-dependent manner and diminished TORC2-mediated phosphorylation of its major downstream effector, protein kinase Ypk1.
Title: Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in cell integrity MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in pexophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of division septum assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of flocculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fungal-type cell wall organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acidic pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stress	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitogen-activated serine/threonine-protein kinase SLT2

NP_011895.1

EC 2.7.11.24

Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

168890..170344 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179160.1 → NP_011895.1 TPA: mitogen-activated serine/threonine-protein kinase SLT2 [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DKX7, Q00772

UniProtKB/TrEMBL

A6ZST6, B3LSF1, C7GTV0, C8ZA99, N1P9L7

Conserved Domains (1) summary

cd07857
Location:22 → 355

STKc_MPK1; Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1