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    DLS1 Dls1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DLS1
    Official Full Name
    Dls1p
    Primary source
    SGD:S000003601
    Locus tag
    YJL065C
    See related
    AllianceGenome:SGD:S000003601; FungiDB:YJL065C; VEuPathDB:YJL065C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein heterodimerization activity. Involved in subtelomeric heterochromatin formation. Acts upstream of or within regulation of DNA double-strand break processing. Located in nucleus. Part of CHRAC. Orthologous to human CHRAC1 (chromatin accessibility complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DLS1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (315054..315557, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase Neighboring gene Mpm1p Neighboring gene mitochondrial 54S ribosomal protein YmL8 Neighboring gene Coa3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. Dang W, et al. J Biol Chem, 2007 Jul 6. PMID 17491017
    2. Histone fold protein Dls1p is required for Isw2-dependent chromatin remodeling in vivo. McConnell AD, et al. Mol Cell Biol, 2004 Apr. PMID 15024052, Free PMC Article
    3. Disruption of six ORFs on Saccharomyces cerevisiae chromosome X: the YJL069c gene of unknown function is essential to cell viability. Vandenbol M, et al. Yeast, 1999 Sep 30. PMID 10509023
    4. Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Iida T, et al. Mol Cell Biol, 2004 Jan. PMID 14673157, Free PMC Article
    5. Comparison of the Isw1a, Isw1b, and Isw2 nucleosome disrupting activities. Krajewski WA. Biochemistry, 2013 Oct 8. PMID 24050724

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CHRAC IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dls1p
    NP_012470.1
    • Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      315054..315557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181498.1 → NP_012470.1  TPA: Dls1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012470.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWB7, P40366
      UniProtKB/TrEMBL
      A6ZPQ7, B3LQ45, C7GR47, C8ZBE8, G2WGV1, N1P8H0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40366.1

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