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    MMM1 ERMES complex subunit MMM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MMM1
    Official Full Name
    ERMES complex subunit MMM1
    Primary source
    SGD:S000003929
    Locus tag
    YLL006W
    See related
    AllianceGenome:SGD:S000003929; FungiDB:YLL006W; VEuPathDB:YLL006W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YME6
    Summary
    Contributes to lipid transfer activity. Involved in aminophospholipid transport; mitochondrion organization; and mitochondrion-endoplasmic reticulum membrane tethering. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Part of ERMES complex. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MMM1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (136586..137866)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Lmo1p Neighboring gene uncharacterized protein Neighboring gene Spo75p Neighboring gene origin recognition complex subunit 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. Burgess SM, et al. J Cell Biol, 1994 Sep. PMID 8089172, Free PMC Article
    2. Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. Kondo-Okamoto N, et al. J Biol Chem, 2003 Dec 5. PMID 12972421
    3. Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate. Laporte D, et al. Elife, 2018 Oct 9. PMID 30299253, Free PMC Article
    4. Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa. Prokisch H, et al. Mol Biol Cell, 2000 Sep. PMID 10982393, Free PMC Article
    5. Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. Hobbs AE, et al. J Cell Biol, 2001 Jan 22. PMID 11266455, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Therefore, the Mmm1-Mdm12 complex functions as a minimal unit that mediates lipid transfer between membranes.
      Title: Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.
    2. Assembly of mitochondrial beta-barrel proteins represents a major function of the morphology proteins Mdm12/Mmm1.
      Title: The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to lipid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to lipid transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aminophospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aminophospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial outer membrane translocase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phospholipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ERMES complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ERMES complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ERMES complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ERMES complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    ERMES complex subunit MMM1
    NP_013095.1
    • ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; localizes to the peroxisome in glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      136586..137866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181826.1 → NP_013095.1  TPA: ERMES complex subunit MMM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0Q0, B5VMT6, D6VXZ7, P41800
      UniProtKB/TrEMBL
      C7GPG3, C8ZCW7, G2WII9, N1NYY2
      Conserved Domains (1) summary
      pfam10296
      Location:95 → 418
      MMM1; Maintenance of mitochondrial morphology protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41800.2

    Gene LinkOut

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