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    RTT109 H3 histone acetyltransferase RTT109 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850658, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RTT109
    Official Full Name
    H3 histone acetyltransferase RTT109
    Primary source
    SGD:S000003925
    Locus tag
    YLL002W
    See related
    AllianceGenome:SGD:S000003925; FungiDB:YLL002W; VEuPathDB:YLL002W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAT11; KIM2; REM50
    Summary
    Enables histone H3 acetyltransferase activity. Involved in DNA metabolic process and regulation of macromolecule metabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTT109 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (146291..147601)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 3 Neighboring gene Sfi1p Neighboring gene dynamin-related GTPase DNM1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pneumocystis jirovecii Rtt109, a novel drug target for Pneumocystis pneumonia in immunosuppressed humans. Dahlin JL, et al. Antimicrob Agents Chemother, 2014 Jul. PMID 24733475, Free PMC Article
    2. Molecular basis for the autoregulation of the protein acetyl transferase Rtt109. Stavropoulos P, et al. Proc Natl Acad Sci U S A, 2008 Aug 26. PMID 18719104, Free PMC Article
    3. DNA replication timing influences gene expression level. Müller CA, et al. J Cell Biol, 2017 Jul 3. PMID 28539386, Free PMC Article
    4. Rtt109 promotes nucleosome replacement ahead of the replication fork. Jonas F, et al. Genome Res, 2022 Jun. PMID 35609993, Free PMC Article
    5. Absence of Rtt109p, a fungal-specific histone acetyltransferase, results in improved acetic acid tolerance of Saccharomyces cerevisiae. Cheng C, et al. FEMS Yeast Res, 2016 Mar. PMID 26851403

    See all (198) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability.
      Title: A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability.
    2. Rtt109 promotes nucleosome replacement ahead of the replication fork.
      Title: Rtt109 promotes nucleosome replacement ahead of the replication fork.
    3. Rtt109 slows replication speed by histone N-terminal acetylation.
      Title: Rtt109 slows replication speed by histone N-terminal acetylation.
    4. Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4.
      Title: Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4.
    5. Data show that H3 histone acetyltransferase RTT109 (Rtt109) C-terminus interacts directly with nucleosome assembly factor ASF1 (Asf1) and the structural basis of this interaction.
      Title: Structural characterization of the Asf1-Rtt109 interaction and its role in histone acetylation.
    6. This replication-guided H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5. Further, topoisomerase depletion intensified H3K9ac in front of the replication fork and in sites where RNA polymerase II was trapped, suggesting supercoiling stresses trigger H3K9 acetylation.
      Title: Chromatin dynamics during DNA replication.
    7. The absence of RTT109 enhanced resistance to 5.5 g L(-1) acetic acid, which was indicated by improved growth of RTT109Delta mutant compared with that of the wild-type BY4741 strain.
      Title: Absence of Rtt109p, a fungal-specific histone acetyltransferase, results in improved acetic acid tolerance of Saccharomyces cerevisiae.
    8. Vps75 and Asf1 both enhance Rtt109 acetylation for H3/H4
      Title: Utilizing targeted mass spectrometry to demonstrate Asf1-dependent increases in residue specificity for Rtt109-Vps75 mediated histone acetylation.
    9. Lys290 in Rtt109 is required in vivo for Vps75 to enhance the activity of the histone acetyltransferase.
      Title: The carboxyl terminus of Rtt109 functions in chaperone control of histone acetylation.
    10. Rtt109-Vps75 preferentially acetylates H3 K9 and K23
      Title: Chaperone-mediated acetylation of histones by Rtt109 identified by quantitative proteomics.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3 acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables histone H3 acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of rDNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    H3 histone acetyltransferase RTT109
    NP_013099.1
    • Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      146291..147601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181822.1 → NP_013099.1  TPA: H3 histone acetyltransferase RTT109 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013099.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY01, Q07794
      UniProtKB/TrEMBL
      A7A0Q4, B3LTG4, C7GPF9, C8ZCX1, G2WIJ3, N1P005
      Conserved Domains (1) summary
      COG5087
      Location:3 → 432
      RTT109; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07794.1

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