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    MET1 uroporphyrinogen-III C-methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MET1
    Official Full Name
    uroporphyrinogen-III C-methyltransferase
    Primary source
    SGD:S000001777
    Locus tag
    YKR069W
    See related
    AllianceGenome:SGD:S000001777; FungiDB:YKR069W; VEuPathDB:YKR069W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MET20
    Summary
    Enables uroporphyrin-III C-methyltransferase activity. Involved in siroheme biosynthetic process. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MET1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (571612..573393)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 Neighboring gene TRAPP complex core subunit BET3 Neighboring gene uncharacterized protein Neighboring gene electron carrier DRE2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Saccharomyces cerevisiae Met1p and Met8p in sirohaem and cobalamin biosynthesis. Raux E, et al. Biochem J, 1999 Mar 15. PMID 10051442, Free PMC Article
    2. Physiological analysis of mutants of Saccharomyces cerevisiae impaired in sulphate assimilation. Thomas D, et al. J Gen Microbiol, 1992 Oct. PMID 1479340
    3. Sulfate assimilation regulates hydrogen sulfide production independent of lifespan and reactive oxygen species under methionine restriction condition in yeast. Choi KM, et al. Aging (Albany NY), 2019 Jun 29. PMID 31254461, Free PMC Article
    4. Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. Hansen J, et al. FEBS Lett, 1997 Jan 13. PMID 9003798
    5. Complex modifier landscape underlying genetic background effects. Hou J, et al. Proc Natl Acad Sci U S A, 2019 Mar 12. PMID 30804202, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uroporphyrin-III C-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uroporphyrin-III C-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uroporphyrin-III C-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siroheme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siroheme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siroheme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    uroporphyrinogen-III C-methyltransferase
    NP_012995.3
    • S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      571612..573393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179859.3 → NP_012995.3  TPA: uroporphyrinogen-III C-methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012995.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXD0, P36150
      UniProtKB/TrEMBL
      G2WI97
      Conserved Domains (2) summary
      COG0007
      Location:323 → 566
      CysG; Uroporphyrinogen-III methylase (siroheme synthase) [Coenzyme transport and metabolism]
      COG1648
      Location:5 → 288
      CysG2; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36150.1

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