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    ATG27 Atg27p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATG27
    Official Full Name
    Atg27p
    Primary source
    SGD:S000003714
    Locus tag
    YJL178C
    See related
    AllianceGenome:SGD:S000003714; FungiDB:YJL178C; VEuPathDB:YJL178C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ETF1
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Involved in cytoplasm to vacuole targeting by the Cvt pathway; macroautophagy; and vesicle organization. Located in several cellular components, including phagophore assembly site; trans-Golgi network; and vacuolar membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATG27 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (89282..90097, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ATP synthase complex assembly protein ATP12 Neighboring gene prefolding complex chaperone subunit Neighboring gene ribosomal 60S subunit protein L17B Neighboring gene Swi3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Atg27 is a second transmembrane cycling protein. Yen WL, et al. Autophagy, 2007 May-Jun. PMID 17297289
    2. Atg27p co-fractionates with clathrin-coated vesicles in budding yeast. Segarra VA, et al. MicroPubl Biol, 2021 Mar 29. PMID 33817564, Free PMC Article
    3. Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy. Wurmser AE, et al. J Cell Biol, 2002 Aug 19. PMID 12186856, Free PMC Article
    4. Kinetic assay of starvation sensitivity in yeast autophagy mutants allows for the identification of intermediary phenotypes. Sturgeon CM, et al. BMC Res Notes, 2019 Aug 14. PMID 31412956, Free PMC Article
    5. Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization. Segarra VA, et al. Traffic, 2015 Apr. PMID 25557545, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAS localization of Atg9 was normal in atg27(DeltaYSAV) cells.
      Title: Atg27 tyrosine sorting motif is important for its trafficking and Atg9 localization.
    2. Overexpression of Atg27 inhibits Atg9 trafficking to the phagophore assembly site.
      Title: Atg23 and Atg27 act at the early stages of Atg9 trafficking in S. cerevisiae.
    3. Atg27 is required for Atg9 cycling and shuttles between the pre-autophagosomal structure, mitochondria, and the Golgi complex.
      Title: Atg27 is required for autophagy-dependent cycling of Atg9.
    4. The unique localization and cycling features of Atg27 suggest the involvement of the Golgi complex in the autophagy pathway.
      Title: Atg27 is a second transmembrane cycling protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to phagophore assembly site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagophore assembly site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Atg27p
    NP_012357.2
    • Type I membrane protein involved in autophagy and the Cvt pathway; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      89282..90097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181611.1 → NP_012357.2  TPA: Atg27p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012357.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW11, P46989, Q86ZR9
      UniProtKB/TrEMBL
      B3LPU7, B5VL11, C7GS04, C8ZB41, G2WGJ7, N1P1W3
      Conserved Domains (1) summary
      pfam09451
      Location:4 → 267
      ATG27; Autophagy-related protein 27
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46989.2

    Gene LinkOut

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