SEN34 tRNA splicing endonuclease subunit SEN34 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SEN34
Official Full Name: tRNA splicing endonuclease subunit SEN34
Primary source: SGD:S000000066
Locus tag: YAR008W
See related: AllianceGenome:SGD:S000000066; FungiDB:YAR008W; VEuPathDB:YAR008W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FUN4
Summary: Enables tRNA-intron endonuclease activity. Involved in tRNA-type intron splice site recognition and cleavage. Located in mitochondrial outer membrane. Part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SEN34 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (158966..159793)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sen34p is absolutely required for tRNA splicing and may affect also rRNA maturation.
Title: Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables tRNA-intron endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-intron endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA-intron endonuclease activity	IEA Inferred from Electronic Annotation more info
enables tRNA-intron endonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	IEA Inferred from Electronic Annotation more info
involved_in tRNA-type intron splice site recognition and cleavage	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA-type intron splice site recognition and cleavage	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA-type intron splice site recognition and cleavage	IEA Inferred from Electronic Annotation more info
involved_in tRNA-type intron splice site recognition and cleavage	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA-intron endonuclease complex	IDA Inferred from Direct Assay more info	PubMed
part_of tRNA-intron endonuclease complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA splicing endonuclease subunit SEN34

NP_009405.1

EC 4.6.1.16

Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

158966..159793

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178212.1 → NP_009405.1 TPA: tRNA splicing endonuclease subunit SEN34 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009405.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPM0, P39707

UniProtKB/TrEMBL

A7A0H1, C7GTB6, G2W8N4

Conserved Domains (1) summary

TIGR00324
Location:94 → 272

endA; tRNA-intron lyase