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    FMP27 Fmp27p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FMP27
    Official Full Name
    Fmp27p
    Primary source
    SGD:S000004446
    Locus tag
    YLR454W
    See related
    AllianceGenome:SGD:S000004446; FungiDB:YLR454W; VEuPathDB:YLR454W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HOB1
    Summary
    Located in mitochondrion. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human BLTP2 (bridge-like lipid transfer protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FMP27 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1043998..1051884)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein SST2 Neighboring gene Rif2p Neighboring gene tRNA-Ile Neighboring gene Pdp3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone occupancy in vivo at the 601 nucleosome binding element is determined by transcriptional history. Perales R, et al. Mol Cell Biol, 2011 Aug. PMID 21690290, Free PMC Article
    2. Gene loops function to maintain transcriptional memory through interaction with the nuclear pore complex. Tan-Wong SM, et al. Genes Dev, 2009 Nov 15. PMID 19933151, Free PMC Article
    3. The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites. Neuman SD, et al. J Cell Sci, 2022 Mar 1. PMID 34415038, Free PMC Article
    4. Complementation Assay Using Fusion of Split-GFP and TurboID (CsFiND) Enables Simultaneous Visualization and Proximity Labeling of Organelle Contact Sites in Yeast. Fujimoto S, et al. Contact (Thousand Oaks), 2023 Jan-Dec. PMID 37366411, Free PMC Article
    5. H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. Fleming AB, et al. Mol Cell, 2008 Jul 11. PMID 18614047

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fmp27p
    NP_013559.1
    • Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles including mitochondria-ER contact sites; non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1043998..1051884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182342.1 → NP_013559.1  TPA: Fmp27p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013559.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ88, Q06179
      UniProtKB/TrEMBL
      A7A1X3, C8ZE60
      Conserved Domains (6) summary
      pfam10293
      Location:938 → 1100
      DUF2405; Domain of unknown function (DUF2405)
      pfam10305
      Location:1178 → 1278
      Fmp27_SW; RNA pol II promoter Fmp27 protein domain
      pfam10344
      Location:19 → 921
      Fmp27; Mitochondrial protein from FMP27
      pfam10347
      Location:1298 → 1456
      Fmp27_GFWDK; RNA pol II promoter Fmp27 protein domain
      pfam10351
      Location:2185 → 2588
      Apt1; Golgi-body localization protein domain
      pfam10359
      Location:1717 → 2173
      Fmp27_WPPW; RNA pol II promoter Fmp27 protein domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06179.1

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