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    CDC65 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDC65
    Primary source
    SGD:S000006690
    Locus tag
    YNCM0036C
    See related
    AllianceGenome:SGD:S000006690
    Gene type
    tRNA
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable triplet codon-amino acid adaptor activity. Involved in mitochondrial translational elongation and regulation of protein localization to nucleus. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDC65 in Genome Data Viewer
    Location:
    chromosome: XIII
    Sequence:
    Chromosome: XIII; NC_001145.3 (808246..808317, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rrn9p Neighboring gene orotate phosphoribosyltransferase URA10 Neighboring gene fatty acid alpha-hydroxylase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exceptional codon recognition by the glutamine tRNAs in Saccharomyces cerevisiae. Edelman I, et al. EMBO J, 1991 Jun. PMID 2026145, Free PMC Article
    2. A yeast glutamine tRNA signals nitrogen status for regulation of dimorphic growth and sporulation. Murray LE, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671727, Free PMC Article
    3. Control of nitrogen catabolite repression is not affected by the tRNAGln-CUU mutation, which results in constitutive pseudohyphal growth of Saccharomyces cerevisiae. Beeser AE, et al. J Bacteriol, 1999 Apr. PMID 10198011, Free PMC Article
    4. A yeast tRNA mutant that causes pseudohyphal growth exhibits reduced rates of CAG codon translation. Kemp AJ, et al. Mol Microbiol, 2013 Jan. PMID 23146061, Free PMC Article
    5. Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase. Grant TD, et al. Nucleic Acids Res, 2012 Apr. PMID 22180531, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    • Glutamine tRNA (tRNA-Gln), predicted by tRNAscan-SE analysis; can mutate to cause constitutive pseudohyphal growth in homozygous diploids; required for localization of transcription factor Gln3p to the nucleus in response to nitrogen starvation or rapamycin treatment

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables triplet codon-amino acid adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables triplet codon-amino acid adaptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

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