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    VAR1 mitochondrial 37S ribosomal protein VAR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VAR1
    Official Full Name
    mitochondrial 37S ribosomal protein VAR1
    Primary source
    SGD:S000007275
    Locus tag
    Q0140
    See related
    AllianceGenome:SGD:S000007275; FungiDB:Q0140; VEuPathDB:Q0140
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    uS3m
    Summary
    A structural constituent of ribosome. Involved in mitochondrial translation. Located in mitochondrial ribosome. Part of mitochondrial small ribosomal subunit. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VAR1 in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (48901..50097)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene F0 ATP synthase subunit c Neighboring gene tRNA-Ser Neighboring gene 21S ribosomal RNA Neighboring gene intron-encoded endonuclease I-SceI Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of mitochondria: a temperature sensitivity mutation affecting the mitochondrially synthesized var1 protein of Saccharomyces cerevisiae. Murphy M, et al. Arch Biochem Biophys, 1980 Aug. PMID 6250484
    2. Respiration deficient mutants in the A+T-rich region on yeast mitochondrial DNA containing the var1 gene. Zassenhaus HP, et al. Curr Genet, 1982 Dec. PMID 24186543
    3. Mitochondrially-encoded protein Var1 promotes loss of respiratory function in Saccharomyces cerevisiae under stressful conditions. Litvinchuk AV, et al. Eur J Cell Biol, 2013 Apr-May. PMID 23523087
    4. The chaperonin-related protein Tcm62p ensures mitochondrial gene expression under heat stress. Klanner C, et al. FEBS Lett, 2000 Mar 31. PMID 10745098
    5. Identification of a cAMP-dependent protein-DNA interaction at a sequence near the yeast mitochondrial rRNA genes. Rahman MU, et al. Biochem Mol Biol Int, 1996 Aug. PMID 8876964

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis.
      Title: The translational activator Sov1 coordinates mitochondrial gene expression with mitoribosome biogenesis.
    2. Var1 physically interacts with mitochondrial DNA and under stress negatively regulates its maintenance.
      Title: Mitochondrially-encoded protein Var1 promotes loss of respiratory function in Saccharomyces cerevisiae under stressful conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial 37S ribosomal protein VAR1
    NP_009320.1
    • Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      48901..50097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009320.1 mitochondrial 37S ribosomal protein VAR1 (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009320.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7NYM3, A2KBL8, P02381, Q95946, Q9ZZW5
      UniProtKB/TrEMBL
      A0A2L1IPY2
      Conserved Domains (1) summary
      pfam05316
      Location:55 → 398
      VAR1; Mitochondrial ribosomal protein (VAR1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02381.3

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