RPR2 ribonuclease P protein subunit RPR2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPR2
Official Full Name: ribonuclease P protein subunit RPR2
Primary source: SGD:S000001454
Locus tag: YIR015W
See related: AllianceGenome:SGD:S000001454; FungiDB:YIR015W; VEuPathDB:YIR015W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to ribonuclease P activity. Involved in intronic box C/D snoRNA processing and tRNA processing. Part of nucleolar ribonuclease P complex. Orthologous to human RPP21 (ribonuclease P/MRP subunit p21). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPR2 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (381948..382382)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P.
Title: Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P.
RNA annealing and strand displacement activities found in archaeal RNase P proteins are prevalent in eubacterial (C5) and eukaryotic (Rpr2) RNase P proteins
Title: Enhancement of RNA annealing and strand displacement found in archaeal ribonuclease P proteins is conserved in Escherichia coli protein C5 and yeast protein Rpr2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to ribonuclease P activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonuclease P activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in intronic box C/D snoRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of endoribonuclease complex	IEA Inferred from Electronic Annotation more info
part_of nucleolar ribonuclease P complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleolar ribonuclease P complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonuclease P protein subunit RPR2

NP_012280.1

EC 3.1.26.5

Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; increases the activity and thermal stability of the complex, along with Pop2p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

381948..382382

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179537.1 → NP_012280.1 TPA: ribonuclease P protein subunit RPR2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012280.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVU5, P40571

UniProtKB/TrEMBL

A6ZVT4, B3LTJ4, C7GJF7, C8ZAR3, G2WGG1, N1P979

Conserved Domains (1) summary

COG2023
Location:24 → 139

RPR2; RNase P subunit RPR2 [Translation, ribosomal structure and biogenesis]