YAP5 Yap5p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YAP5
Official Full Name: Yap5p
Primary source: SGD:S000001457
Locus tag: YIR018W
See related: AllianceGenome:SGD:S000001457; FungiDB:YIR018W; VEuPathDB:YIR018W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cellular response to iron ion; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YAP5 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (384609..385346)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae.
Title: DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae.
Fe/S cluster binding to Yap5-activator domain induces a conformational change that may activate transcription
Title: The basic leucine zipper stress response regulator Yap5 senses high-iron conditions by coordination of [2Fe-2S] clusters.
loss of activity of the cytosolic iron-sulfur cluster assembly complex proteins or deletion of cytosolic glutaredoxins did not reduce expression of Yap5 target genes
Title: A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast.
we propose that under Fe-adequacy Yap5 is activated leading to the upregulation of CCC1 with the consequent accumulation of Fe in the vacuole and deprivation of the cytosolic iron pool.
Title: The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.
the Yap5-mediated induction of TYW1 provides protection from high iron toxicity by the consumption of free cytosolic iron through the formation of protein-bound iron-sulfur clusters
Title: Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity.
These results show that Yap5 is an iron-sensing transcription factor and that iron regulates transcriptional activation.
Title: Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to iron ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Yap5p

NP_012283.1

Basic leucine zipper (bZIP) iron-sensing transcription factor; senses high-iron conditions via two Fe/S clusters bound to its activator domain; involved in diauxic shift; YAP5 has a paralog, YAP7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

384609..385346

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179540.1 → NP_012283.1 TPA: Yap5p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012283.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVU8, P40574

UniProtKB/TrEMBL

A6ZVT7, B3LTJ1, B5VKV3, C7GJF5, C8ZAR7, N1P1S6

Conserved Domains (1) summary

cd14688
Location:59 → 121

bZIP_YAP; Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain