MET18 Met18p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET18
Official Full Name: Met18p
Primary source: SGD:S000001390
Locus tag: YIL128W
See related: AllianceGenome:SGD:S000001390; FungiDB:YIL128W; VEuPathDB:YIL128W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MMS19
Summary: Involved in protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MET18 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (113806..116904)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MET18 deficiency diminished the replicative capacity of yeast cells as evidenced by the shortened replicative lifespan, which can be restored by CTT1 overexpression, but not by CTA1, in the MET18-deficient cells.
Title: MET18 Deficiency Increases the Sensitivity of Yeast to Oxidative Stress and Shortens Replicative Lifespan by Inhibiting Catalase Activity.
identified MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery; MMS19 functions as part of the CIA targeting complex that interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance
Title: MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation by iron-sulfur cluster transfer	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
part_of cytosolic [4Fe-4S] assembly targeting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic [4Fe-4S] assembly targeting complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Met18p

NP_012138.1

Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

113806..116904

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179476.1 → NP_012138.1 TPA: Met18p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012138.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVF9, P40469, P89106, Q45U11

UniProtKB/TrEMBL

B3LTX5, N1P0T9

Conserved Domains (2) summary

pfam12460
Location:567 → 953

MMS19_C; RNAPII transcription regulator C-terminal

pfam14500
Location:49 → 313

MMS19_N; Dos2-interacting transcription regulator of RNA-Pol-II