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    SIM1 putative glucosidase SIM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SIM1
    Official Full Name
    putative glucosidase SIM1
    Primary source
    SGD:S000001385
    Locus tag
    YIL123W
    See related
    AllianceGenome:SGD:S000001385; FungiDB:YIL123W; VEuPathDB:YIL123W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable hydrolase activity, acting on glycosyl bonds. Involved in fungal-type cell wall organization. Located in fungal-type cell wall. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SIM1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (128151..129581)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene alpha-ketoglutarate dehydrogenase KGD1 Neighboring gene acylglycerone-phosphate reductase Neighboring gene Pog1p Neighboring gene cation transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity. Mouassite M, et al. FEMS Microbiol Lett, 2000 Jan 1. PMID 10612745
    2. In Vivo-In Vitro Comparative Toxicology of Cadmium Sulphide Quantum Dots in the Model Organism Saccharomyces cerevisiae. Pagano L, et al. Nanomaterials (Basel), 2019 Apr 2. PMID 30986968, Free PMC Article
    3. Dual cell wall/mitochondria localization of the 'SUN' family proteins. Velours G, et al. FEMS Microbiol Lett, 2002 Feb 5. PMID 11958935
    4. SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level. Kuznetsov E, et al. PLoS One, 2013. PMID 24040106, Free PMC Article
    5. Pag1p, a novel protein associated with protein kinase Cbk1p, is required for cell morphogenesis and proliferation in Saccharomyces cerevisiae. Du LL, et al. Mol Biol Cell, 2002 Feb. PMID 11854408, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ssd1 regulates translation of its target message primarily through UTRs and the SIM1 message through multiple potential points of interaction, permitting fine translational control in various contexts.
      Title: Cell morphogenesis proteins are translationally controlled through UTRs by the Ndr/LATS target Ssd1.
    2. SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
      Title: SUN family proteins Sun4p, Uth1p and Sim1p are secreted from Saccharomyces cerevisiae and produced dependently on oxygen level.
    3. TORC2 has been shown previously to negatively regulate calcineurin in part by phosphorylating two related proteins, Slm1 and Slm2, which associate with the PM via plextrin homology domains
      Title: Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative glucosidase SIM1
    NP_012143.2
    • Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      128151..129581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179471.2 → NP_012143.2  TPA: putative glucosidase SIM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012143.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBN1, D6VVG4, P40472, Q45U06, Q870H1
      UniProtKB/TrEMBL
      B3LTX0, N1P9A4
      Conserved Domains (1) summary
      pfam03856
      Location:221 → 462
      SUN; Beta-glucosidase (SUN family)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40472.2

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