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    MPC2 mitochondrial pyruvate carrier [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856567, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MPC2
    Official Full Name
    mitochondrial pyruvate carrier
    Primary source
    SGD:S000001205
    Locus tag
    YHR162W
    See related
    AllianceGenome:SGD:S000001205; FungiDB:YHR162W; VEuPathDB:YHR162W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyruvate transmembrane transporter activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. Orthologous to human MPC2 (mitochondrial pyruvate carrier 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MPC2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (423072..423461)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Pex18p Neighboring gene Yap1801p Neighboring gene 6-phosphogluconolactonase SOL3 Neighboring gene bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes. Wang Z, et al. Biomolecules, 2023 Apr 22. PMID 37238591, Free PMC Article
    2. Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes. Bender T, et al. EMBO J, 2015 Apr 1. PMID 25672363, Free PMC Article
    3. The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state. Tavoulari S, et al. EMBO J, 2019 May 15. PMID 30979775, Free PMC Article
    4. Differential regulation of mitochondrial pyruvate carrier genes modulates respiratory capacity and stress tolerance in yeast. Timón-Gómez A, et al. PLoS One, 2013. PMID 24244496, Free PMC Article
    5. Methionine supplementation stimulates mitochondrial respiration. Tripodi F, et al. Biochim Biophys Acta Mol Cell Res, 2018 Dec. PMID 30290237

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
      Title: NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
    2. MPC is a hetero-dimer, not a multimeric complex. When not engaged in hetero-dimers, the yeast Mpc proteins can also form homo-dimers that are, however, inactive.
      Title: The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.
    3. while expression of Mpc1 is not dependent on the carbon source, expression of Mpc2 and Mpc3 is specific to fermentative or respiratory conditions, respectively. This gives rise to two alternative carrier complexes
      Title: Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.
    4. study concludes that the mitochondrial pyruvate carrier is composed of Mpc1(Ygl080w) and either Mpc2 (Yhr162w) or Mpc3 (Ygr243w); members of the MPC family were found in the inner mitochondrial membrane; mutants lacking MPC proteins showed severe defects in mitochondrial pyruvate uptake
      Title: Identification and functional expression of the mitochondrial pyruvate carrier.
    5. Mpc1 (YGL080W )and Mpc2 (YHR162W) associate to form a complex in the inner mitochondrial membrane; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier
      Title: A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables pyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate transmembrane transporter activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial pyruvate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial pyruvate transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial pyruvate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial pyruvate carrier
    NP_012032.1
    • Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      423072..423461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179293.1 → NP_012032.1  TPA: mitochondrial pyruvate carrier [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLB1, P38857
      UniProtKB/TrEMBL
      A6ZT70, B3LSS6, C7GJX7, C8Z9V9, G2WFN6, N1P2E3
      Conserved Domains (1) summary
      pfam03650
      Location:9 → 118
      MPC; Uncharacterized protein family (UPF0041)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38857.1

    Gene LinkOut

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