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    MTG2 putative GTPase MTG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MTG2
    Official Full Name
    putative GTPase MTG2
    Primary source
    SGD:S000001211
    Locus tag
    YHR168W
    See related
    AllianceGenome:SGD:S000001211; FungiDB:YHR168W; VEuPathDB:YHR168W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ribosome binding activity. Involved in cytoplasmic translation. Located in mitochondrial inner membrane. Orthologous to several human genes including MTG2 (mitochondrial ribosome associated GTPase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MTG2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (440377..441933)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit CDC23 Neighboring gene Thp2p Neighboring gene ATP-dependent RNA helicase DBP8 Neighboring gene ribosome-binding protein NMD3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2. Datta K, et al. Mol Biol Cell, 2005 Feb. PMID 15591131, Free PMC Article
    2. Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Merz S, et al. Genome Biol, 2009. PMID 19751518, Free PMC Article
    3. Mitochondrial ER contacts are crucial for mitophagy in yeast. Böckler S, et al. Dev Cell, 2014 Feb 24. PMID 24530295
    4. The ribosome receptors Mrx15 and Mba1 jointly organize cotranslational insertion and protein biogenesis in mitochondria. Möller-Hergt BV, et al. Mol Biol Cell, 2018 Oct 1. PMID 30091672, Free PMC Article
    5. The zinc-finger transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay. Kelbert M, et al. Elife, 2024 Oct 2. PMID 39356734, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative GTPase MTG2
    NP_012038.2
    • Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      440377..441933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179299.2 → NP_012038.2  TPA: putative GTPase MTG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012038.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLB7, P38860, Q6DUF2
      UniProtKB/TrEMBL
      C7GJX2, G2WFP2, N1P9H5
      Conserved Domains (1) summary
      COG0536
      Location:90 → 509
      Obg; GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, chromosome partitioning, Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38860.2

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