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    SKI6 exosome non-catalytic core subunit SKI6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SKI6
    Official Full Name
    exosome non-catalytic core subunit SKI6
    Primary source
    SGD:S000003427
    Locus tag
    YGR195W
    See related
    AllianceGenome:SGD:S000003427; FungiDB:YGR195W; VEuPathDB:YGR195W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ECM20; RRP41
    Summary
    Predicted to enable RNA binding activity. Involved in RNA metabolic process. Located in nucleolus. Part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Used to study developmental disorder of mental health. Orthologous to human EXOSC4 (exosome component 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SKI6 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (888882..889622)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Pdx1p Neighboring gene xylulokinase Neighboring gene Fyv8p Neighboring gene Sng1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The complete sequence of a 9000 bp fragment of the right arm of Saccharomyces cerevisiae chromosome VII contains four previously unknown open reading frames. Guerreiro P, et al. Yeast, 1995 Sep 15. PMID 7502584
    2. Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8 S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells. Chekanova JA, et al. J Biol Chem, 2000 Oct 20. PMID 10930416
    3. Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs. Torchet C, et al. Mol Cell, 2002 Jun. PMID 12086625
    4. 3' poly(A) is dispensable for translation. Searfoss AM, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922069, Free PMC Article
    5. Ski6p is a homolog of RNA-processing enzymes that affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis. Benard L, et al. Mol Cell Biol, 1998 May. PMID 9566888, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAMP-dependent tRNA surveillance pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in TRAMP-dependent tRNA surveillance pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U1 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U1 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U4 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U4 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in U5 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U5 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent CUT catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exosome non-catalytic core subunit SKI6
    NP_011711.3
    • Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      888882..889622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181324.3 → NP_011711.3  TPA: exosome non-catalytic core subunit SKI6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011711.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUX7, P46948
      UniProtKB/TrEMBL
      A6ZUK5, B3LI42, B5VJD7, C7GRM7, C8Z988, G2WES3, N1P625
      Conserved Domains (1) summary
      cd11370
      Location:11 → 237
      RNase_PH_RRP41; RRP41 subunit of eukaryotic exosome
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46948.1

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