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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853020, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000003354
    Locus tag
    YGR122W
    See related
    AllianceGenome:SGD:S000003354; FungiDB:YGR122W; VEuPathDB:YGR122W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in negative regulation of transcription by RNA polymerase II and nuclear-transcribed mRNA catabolic process, non-stop decay. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (733935..735143)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ammonium permease MEP1 Neighboring gene uncharacterized protein Neighboring gene tRNA-Arg Neighboring gene protein serine/threonine phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PalC, one of two Bro1 domain proteins in the fungal pH signalling pathway, localizes to cortical structures and binds Vps32. Galindo A, et al. Traffic, 2007 Oct. PMID 17696968, Free PMC Article
    2. Relationship of DFG16 to the Rim101p pH response pathway in Saccharomyces cerevisiae and Candida albicans. Barwell KJ, et al. Eukaryot Cell, 2005 May. PMID 15879523, Free PMC Article
    3. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method. Xie MW, et al. Proc Natl Acad Sci U S A, 2005 May 17. PMID 15883373, Free PMC Article
    4. Interaction maps of the Saccharomyces cerevisiae ESCRT-III protein Snf7. Sciskala B, et al. Eukaryot Cell, 2013 Nov. PMID 24058170, Free PMC Article
    5. Protein interaction verification and functional annotation by integrated analysis of genome-scale data. Kemmeren P, et al. Mol Cell, 2002 May. PMID 12049748

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_011637.3
    • Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      733935..735143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181251.3 → NP_011637.3  TPA: uncharacterized protein YGR122W [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011637.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ4, P53272
      UniProtKB/TrEMBL
      A6ZUD6, B3LIA6, C7GSX3, C8Z914, N1P419
      Conserved Domains (1) summary
      pfam17306
      Location:80 → 402
      DUF5355; Family of unknown function (DUF5355)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53272.1

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